Generic
Metformin Hydrochloride 500mg is the active ingredient in Bigmet 500 tablets manufactured by Renata Pharma Ltd.

Description
BBig met500 is an oral antihyperglycemic medication of the biguanide class designed to treat type 2 diabetes. It effectively controls blood sugar levels without causing hypoglycemia.

Benefits
Big Met 500 helps reduce blood sugar levels, enhances insulin sensitivity, and minimizes diabetic complications, especially in overweight patients with type 2 diabetes.

Ingredients
Each tablet contains 500mg of Metformin Hydrochloride as the primary active ingredient.

Uses and DosesBig Mett 500 is used for managing type 2 diabetes. Adults start with 500 mg twice daily with meals, gradually increasing to a maximum of 2000 daily. For children aged 10 and above, the starting dose is 500 mg twice daily, increasing weekly to a maximum of 2000 mg.

Side Effects
Common side effects include gastrointestinal discomfort, nausea, vomiting, and diarrhea. Rare effects include vitamin B12 deficiency, lactic acidosis, and skin reactions like erythema or pruritus.

How to Use
Swallow the tablet whole with meals to prevent gastrointestinal discomfort. Do not crush, cut, or chew the tablet. Follow the prescribed dosage and consult your doctor for adjustments.

Pregnancy & Lactation
Big met 500 is not recommended during pregnancy; insulin is preferred for better glycemic control. Because metformin passes into breast milk, breastfeeding is generally discouraged.

Precautions and Warnings
Patients with impaired renal function (eGFR below 30 mL/min/1.73 m²) should not use Bigmet 500. Instead, renal function and vitamin B12 levels should be regularly monitored.

Safety Information
Do not use Bigmet 500 with acute metabolic acidosis or severe conditions that impair renal or hepatic function. Avoid alcohol to reduce the risk of lactic acidosis.

Indications
Bigmet 500 is indicated for managing type 2 diabetes in adults and children aged 10 or older, either as monotherapy or in combination with insulin.

Pharmacology
Metformin reduces glucose production in the liver, improves peripheral glucose uptake, and enhances insulin sensitivity. It is effective in controlling fasting and postprandial blood glucose levels.

Therapeutic Class
Biguanides.

Storage Conditions
Store below 30°C, away from light and moisture. Keep outchildren'sen's reach.

3 FAQ

1. Can children use Bigmet 500?
   Children aged 10 years and older can use it with appropriate dosage adjustments.
2. Does Bigmet 500 cause hypoglycemia?
   No, it typically does not cause hypoglycemia when used alone.
3. Can I use Bigmet 500I? I’m breastfeeding.
   It is not recommended due to potential risks to the infant.

Disclaimer
This information is for educational purposes only and does not replace medical advice. Consult a healthcare professional for personalized recommendations.

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