Generic

Lactulose

Description

Avolac 100ml is an oral solution containing Lactulose, a synthetic disaccharide, designed primarily for relieving chronic constipation. It draws water into the colon to soften stools and improve bowel movement. Additionally, Avolac is used in managing hepatic encephalopathy by lowering ammonia levels in the blood, reducing symptoms like confusion and tremors related to liver disease.

Benefits

Avolac’s formulation provides effective constipation relief by enhancing stool consistency, easing passage, and reducing the discomfort associated with difficult bowel movements. It also improves gut health, helping to restore normal bowel function in cases of disrupted intestinal flora. For hepatic encephalopathy, Avolac is beneficial in reducing blood ammonia, aiding patients with liver conditions.

Ingredients

The main active ingredient in Avolac is Lactulose, providing 3.35g per 100ml. Lactulose is a non-absorbable sugar, making it effective for its laxative properties without significant systemic effects.

Uses and Doses

Constipation (Chronic): Adults: Initial dose of 3-6 teaspoons daily; maintenance 1.5-6 teaspoons.
Children (up to 14 years): 3 teaspoons initially, reducing to 1-2 teaspoons daily.
Infants: 1-2 teaspoons initially, maintenance 1 teaspoon daily.

Intestinal Flora Imbalance:
Adults: 1-2 teaspoons daily
Children: 1 teaspoon daily

Hepatic Encephalopathy:
For acute conditions, administer hourly doses of 6-9 teaspoons until laxation is achieved. Maintenance doses are tailored to achieve 2-3 soft stools daily.

Side Effects

Common side effects include flatulence, abdominal cramps, and nausea, especially when treatment begins. High doses may cause diarrhea and electrolyte imbalances such as potassium loss. Long-term use should be monitored by a doctor to avoid side effects from prolonged stool softening.

How to Use

Take Avolac by mouth using the prescribed dose, ideally at the same time daily. Shake well before each dose and use a measuring cup for accuracy. This solution can be taken with or without food, though it is recommended at a fixed time for maximum effectiveness.

Pregnancy & Lactation

Classified under US FDA Pregnancy Category B, Avolac shows no adverse effects based on current studies. Pregnant and breastfeeding individuals should consult their healthcare provider before use.

Precautions and Warnings

Avolac is not recommended for patients with galactosemia or intestinal obstruction. Caution is advised in lactose-intolerant patients and those with diabetes due to the sugar-based formulation. It may impact potassium levels, so patients should be monitored for electrolyte imbalance in long-term use.

Safety Information

Avolac may intensify the effects of cardiac glycosides in case of potassium deficiency, and caution should be used in patients on such medication. Avoid concomitant use with antacids, which may decrease lactulose’s efficacy.

Indications

Avolac is indicated for the treatment of chronic constipation, hepatic encephalopathy, and as supportive therapy for restoring intestinal flora, especially after antibiotic treatment.

Pharmacology

Lactulose is metabolized in the colon, where it is converted to lactic acid, lowering colon pH and increasing water content in the stool. This osmosis-driven action stimulates peristalsis and bowel movement. In hepatic encephalopathy, it helps reduce blood ammonia levels, alleviating symptoms by reducing gut absorption of toxic nitrogenous compounds.

Therapeutic Class

Osmotic Purgatives

Storage Conditions

Store in a dry, cool place away from direct light and heat, and out of reach of children. The recommended storage temperature is below 25°C.

FAQ

1. How quickly does Avolac work?
It typically takes 24-48 hours to produce a bowel movement. If constipation persists beyond 3 days, consult your physician.

2. Can I use Avolac for children?
Yes, Avolac is safe for children in adjusted dosages, but always consult a pediatrician before use.

3. Can I take Avolac with other laxatives?
Avoid combining with other laxatives unless recommended by a healthcare provider to prevent excessive stool softening.

Disclaimer

This information does not replace professional medical advice. Always consult your physician or healthcare provider for personalized medical advice, particularly regarding dosage and long-term use.

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