Pregabalin

Description
Nervalin 25 is a capsule containing Pregabalin 25mg, prescribed primarily for neuropathic pain and epilepsy management. Manufactured by Beximco Pharmaceuticals Ltd., Nervalin 25 offers effective relief for diabetic peripheral neuropathy, fibromyalgia, and pain due to spinal cord injuries. It binds to alpha-2-delta receptors in the CNS, minimizing pain sensations. Prescription-only medication, it ensures a targeted approach to pain and neurological conditions.

Benefits
Nervalin 25 provides substantial relief from various forms of neuropathic pain, supports seizure control in patients with partial onset seizures, and enhances overall quality of life by alleviating symptoms associated with fibromyalgia and spinal cord injury-related pain. Its high bioavailability and limited interaction with other medications make it suitable for multi-drug regimens.

Ingredients
Pregabalin 25 mg

Uses and Doses

• Neuropathic Pain (Diabetic Neuropathy): Start with 50 mg three times daily, may increase to 300 mg/day based on tolerance.
• Post-herpetic Neuralgia: Initial dose of 75 mg twice daily, adjustable up to 300 mg/day.
• Partial Onset Seizures: Begin at 150 mg/day; may increase to a maximum of 600 mg/day.
• Fibromyalgia: Starting dose of 150 mg/day, potentially increasing to 300-450 mg/day.
• Spinal Cord Injury Pain: Start with 150 mg/day, titrate up to 600 mg/day as tolerated.

Side Effects
Common side effects of Pregabalin include dizziness, somnolence, dry mouth, edema, vision impairment, weight gain, and changes in thought processes.

How to Use
Take Nervalin 25 orally, with or without food. Dosage should be followed as prescribed by your doctor. Gradual dose adjustment is advised for stopping the medication to avoid withdrawal symptoms.

Pregnancy & Lactation
Pregabalin is a Category C drug, recommended only if benefits justify the potential fetal risk. It may pass into breast milk and should be used cautiously in nursing mothers.

Precautions and Warnings
Abrupt discontinuation can cause withdrawal symptoms; gradual tapering is recommended. Monitor creatinine kinase levels if myopathy is suspected. Discontinue if unusually high levels or muscle pain occur.

Safety Information
Store below 30° C, in a dry, cool environment, protected from light and moisture. Keep out of reach of children.

Indications
Indicated for treating neuropathic pain (diabetic neuropathy), post-herpetic neuralgia, fibromyalgia, and partial onset seizures.

Pharmacology
Pregabalin, a gamma-aminobutyric acid (GABA) derivative, interacts with the alpha-2-delta site on calcium channels in CNS tissue, reducing pain and seizure frequency. It is excreted by the kidneys with a half-life of about 6.3 hours in individuals with normal renal function.

Therapeutic Class
Adjunct anti-epileptic drugs.

Storage Conditions
Store in a cool, dry place, below 30° C. Protect from light and moisture.

3 FAQ

1. Can Pregabalin be taken without food?
   Yes, Pregabalin capsules can be taken with or without food.
2. What should I do if I miss a dose?
   Take the missed dose as soon as possible, unless it’s almost time for the next one. Do not double up on doses.
3. Is Nervalin 25 safe for long-term use?
   Pregabalin is safe for extended use under medical supervision; follow your doctor’s guidance on dosage adjustments and monitoring.

   Disclaimer
   This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a healthcare provider for medical guidance related to dosage, side effects, and interactions with other drugs.

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