Generic

Naprox Plus 500 contains two primary generics: Naproxen Sodium 500mg and Esomeprazole 20mg. These active ingredients work in combination to relieve pain and reduce the risk of gastric ulcers associated with NSAID use.

Description

Naprox Plus 500 is a prescription medication manufactured by Eskayef Pharmaceuticals Ltd. It combines the pain-relieving effects of Naproxen Sodium with the acid-reducing benefits of Esomeprazole, providing comprehensive treatment for arthritis-related symptoms while protecting the stomach.

Benefits

Naprox Plus 500 offers dual-action relief by reducing arthritis-related inflammation and lowering the risk of gastric ulcers. It provides long-lasting pain relief and allows patients to manage their symptoms safely, minimizing stomach discomfort associated with NSAID use.

Ingredients

Each Naprox Plus 500 tablet contains 500 mg of Naproxen Sodium, a nonsteroidal anti-inflammatory drug (NSAID), and 20 mg of Esomeprazole Magnesium, a proton pump inhibitor (PPI).

Uses and Doses

Naprox Plus 500 is recommended for managing osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Adults should take one tablet twice daily, 375 mg/20 mg or 500 mg/20 mg, as prescribed. The tablet should be taken whole, at least 30 minutes before meals, without chewing or crushing.

Side Effects

Common side effects may include dyspepsia, gastritis, diarrhea, upper abdominal discomfort, nausea, and gastric ulcers. Most patients tolerated Naprox Plus 500 well in clinical trials, though adverse reactions were possible.

How to Use

Take one Naprox Plus 500 tablet whole with water, ideally 30 minutes before meals. Avoid splitting, chewing, crushing, or dissolving the tablet. Follow the prescribed dosage and consult your healthcare provider for tailored guidance.

Pregnancy & Lactation

Naprox Plus 500 falls under Pregnancy Category C, suggesting it should be avoided during late pregnancy as it may affect fetal development. Nursing mothers are also advised not to use this medication due to the Naproxen component.

Precautions and Warnings

Patients with cardiovascular disease or fluid retention should use Naprox Plus 500 cautiously. Those with heart failure, high blood pressure, or a history of heart conditions are at higher risk of complications.

Safety Information

Consult a healthcare provider before using Naprox Plus 500 if taking other medications, as certain combinations may affect its effectiveness or increase side effects. Do not use if allergic to NSAIDs or any tablet component.

Indications

Naprox Plus 500 is indicated for treating osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis symptoms. It also reduces the risk of NSAID-related gastric ulcers.

Pharmacology

Naprox Plus 500 has a dual-layer formulation where Esomeprazole dissolves first to protect the stomach, followed by Naproxen release in the small intestine. Naproxen inhibits prostaglandin production, reducing pain and inflammation, while Esomeprazole decreases gastric acid production.

Therapeutic Class

Naprox Plus 500 belongs to the therapeutic class of nonsteroidal anti-inflammatory drugs (NSAIDs) and drugs for osteoarthritis and rheumatoid arthritis.

Storage Conditions

Store Naprox Plus 500 in a cool, dry place, away from light, and below 30°C. Keep out of reach of children.

FAQ

1. Can I take Naprox Plus 500 on an empty stomach?
   • Taking it at least 30 minutes before meals is recommended to protect the stomach lining.
2. Can I use Naprox Plus 500 for long-term treatment?
   • This medication should be taken for the shortest duration possible under medical supervision.
3. Is Naprox Plus 500 safe for those with high blood pressure?
   • Patients with high blood pressure should consult a healthcare provider, as NSAIDs can affect cardiovascular health.

Disclaimer

This information is provided for general knowledge and should not replace medical advice. Always consult your healthcare provider before starting any new medication, including Naprox Plus 500.

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