Generic

Janmet 500 is a combination medication containing Sitagliptin and Metformin, designed to control blood sugar levels in adults with type 2 diabetes mellitus. It works by supporting the body’s insulin production and usage and by reducing liver glucose output, effectively managing blood sugar.

Description

Janmet 500 is a dual-action antidiabetic medication that integrates Sitagliptin and Metformin to help manage blood glucose in patients with type 2 diabetes mellitus. This medication can be prescribed alone or in combination with other diabetes treatments. It is most effective when combined with a healthy lifestyle, including a balanced diet and regular exercise.

Benefits

Janmet 500 assists in managing high blood sugar levels, which may prevent complications of diabetes such as kidney damage, blindness, and cardiovascular issues. It aids the pancreas in producing insulin, enhances insulin utilization, and reduces glucose production in the liver. Additionally, it is known for causing fewer instances of hypoglycemia and weight gain compared to other diabetes medications.

Ingredients

Janmet 500 combines two active ingredients: Sitagliptin and Metformin. Sitagliptin belongs to the dipeptidyl peptidase-4 (DPP-4) inhibitor class, which enhances incretin hormones to boost insulin synthesis. Metformin, a biguanide, reduces glucose production in the liver, enhances peripheral glucose uptake, and increases insulin sensitivity.

Uses and Doses

Janmet 500 is primarily used to manage type 2 diabetes mellitus in adults. It should be taken with food as prescribed by a healthcare professional. The dosage varies depending on factors such as blood sugar levels, existing medications, and individual tolerability. Typically, patients start with 50 mg of Sitagliptin and 500 mg of Metformin twice daily, with the possibility of dose adjustment based on effectiveness and tolerability.

Side Effects

Common side effects may include diarrhea, nausea, vomiting, stomach discomfort, headache, sore throat, nasal congestion, and respiratory infections. In combination with insulin or sulfonylureas, Janmet 500 may cause hypoglycemia. Rare side effects include lactic acidosis, Stevens-Johnson syndrome, anaphylaxis, and acute renal failure. Patients should report any unusual symptoms to their healthcare provider.

How to Use

Take Janmet 500 precisely as prescribed by your doctor. Swallow the tablet whole with a meal to reduce gastrointestinal side effects. Do not chew, crush, or break the tablet. It’s important to maintain consistency by taking the medication at the same time each day for optimal blood sugar control.

Pregnancy & Lactation

The safety of Janmet 500 during pregnancy and lactation is not established. Pregnant or breastfeeding women should consult their healthcare provider before using this medication, as caution is advised due to potential risks.

Precautions and Warnings

Janmet 500 is not suitable for patients with type 1 diabetes or diabetic ketoacidosis. It should be used cautiously in patients with renal or hepatic impairments and those at risk for lactic acidosis. Avoid alcohol consumption as it can lower blood sugar levels and increase the risk of lactic acidosis. Always inform your healthcare provider of any other medications you are taking.

Safety Information

Before using Janmet 500, inform your healthcare provider if you have a history of kidney, liver, or heart disease, pancreatitis, or alcohol use. Regular kidney function tests and blood sugar monitoring are recommended. Discontinue use if symptoms of pancreatitis or lactic acidosis occur.

Indications

Janmet 500 is indicated for managing type 2 diabetes mellitus in adults. It helps control blood sugar levels in patients who are unable to manage their condition through diet and exercise alone.

Pharmacology

Sitagliptin is a DPP-4 inhibitor that increases and prolongs the activity of incretin hormones, which stimulate insulin synthesis and reduce glucagon release. Metformin, a biguanide, lowers glucose production in the liver, improves insulin sensitivity, and enhances glucose uptake in peripheral tissues, reducing both basal and postprandial plasma glucose.

Therapeutic Class

Janmet 500 belongs to the antidiabetic therapeutic class, specifically a combination of a DPP-4 inhibitor and a biguanide.

Storage Conditions

Store Janmet 500 in a cool, dry place away from direct sunlight. Keep the medication out of reach of children. Do not store above 30°C.

3 FAQ

Q1: Can Janmet 500 be taken with other diabetes medications?
A: Yes, Janmet 500 can be prescribed alongside other diabetes medications, but always consult your doctor before combining treatments.

Q2: What should I do if I miss a dose?
A: If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue as usual. Do not double up doses.

Q3: Is Janmet 500 suitable for type 1 diabetes?
A: No, Janmet 500 is not indicated for type 1 diabetes or diabetic ketoacidosis.

Disclaimer

This information is intended for educational purposes only and should not replace medical advice. Always consult a healthcare provider for guidance on medication use, potential side effects, and treatment plans.

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