Generic

Empagliflozin + Linagliptin

Description

Glinta Plus 10/5 is a combination tablet of Empagliflozin and Linagliptin. It is specifically designed to aid in managing type 2 diabetes by improving glycemic control when used alongside a proper diet and exercise plan.

Benefits

This combination tablet offers dual benefits: Empagliflozin aids in glucose excretion via urine, reducing blood glucose levels, while Linagliptin improves insulin secretion and reduces glucagon production by inhibiting the DPP-4 enzyme. Together, they help maintain glucose homeostasis and reduce complications associated with type 2 diabetes.

Ingredients

Each tablet contains:

• Empagliflozin 10 mg
• Linagliptin 5 mg

Uses and Doses

Glinta Plus is indicated for improving glycemic control in adults with type 2 diabetes. The recommended dose is one tablet (10 mg Empagliflozin + 5 mg Linagliptin) taken once daily, in the morning, with or without food. For patients needing increased glycemic control, the dose may be adjusted to 25 mg Empagliflozin with 5 mg Linagliptin daily. Dosage adjustments are necessary for patients with renal impairments, especially those with eGFR below 45 mL/min/1.73 m².

Side Effects

Common side effects include urinary tract infections, genital infections, and hypoglycemia when taken alongside insulin or insulin secretagogues. Rare but severe side effects include pancreatitis, ketoacidosis, volume depletion, and necrotizing fasciitis of the perineum.

How to Use

Take the tablet orally once a day in the morning. It can be consumed with or without food. Ensure consistent timing for better efficacy.

Pregnancy & Lactation

This medication is not recommended during the second and third trimesters of pregnancy due to potential risks to the fetus. The limited data available on its use in pregnancy are insufficient to determine the risk for major birth defects or miscarriage.

Precautions and Warnings

Caution is advised in conditions like pancreatitis, renal impairment, ketoacidosis, and volume depletion. Patients with urinary tract infections or prone to genital infections should use this medicine under strict medical supervision. Avoid using this medication if there is a history of hypersensitivity to its components.

Safety Information

Patients should avoid combining Glinta Plus with strong CYP3A4 inducers or diuretics without consulting their physician. Regular monitoring of kidney function is recommended.

Indications

Glinta Plus is primarily indicated as an adjunct to diet and exercise for the treatment of type 2 diabetes mellitus in adults.

Pharmacology

Empagliflozin works by inhibiting the SGLT2 protein in the kidneys, enhancing glucose excretion through urine and reducing blood glucose levels. Linagliptin inhibits the DPP-4 enzyme, increasing incretin hormone levels, enhancing insulin release, and decreasing glucagon levels to regulate blood glucose.

Therapeutic Class

Sodium-glucose co-transporter 2 (SGLT2) inhibitors

Storage Conditions

Store at temperatures below 30°C. Keep away from light and moisture. Ensure the medication is out of children’s reach.

3 FAQ

1. Can Glinta Plus be taken during pregnancy?
   It is not recommended during the second and third trimesters due to potential risks. Consult a healthcare provider for alternatives.
2. What are the most common side effects?
   Common side effects include urinary and genital infections, as well as hypoglycemia when combined with insulin.
3. Is Glinta Plus safe for patients with kidney problems?
   Dose adjustments are necessary for patients with renal impairments, and the medication is contraindicated for those with severe kidney issues or dialysis patients.

Disclaimer

This information is provided for educational purposes and should not replace medical advice. Always consult your healthcare provider before starting or discontinuing any medication.

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