Generic
The active ingredient in Contine 400 is Theophylline, a widely used bronchodilator medication from Aristopharma Ltd.

Description
Contine 400 is a prescription bronchodilator formulated to help manage asthma, chronic obstructive pulmonary disease (COPD), and apnea in premature infants. This xanthine derivative tablet offers effective relief from respiratory conditions marked by bronchospasm and air passage blockages.

Benefits
Contine 400 alleviates symptoms of asthma, COPD, and chronic bronchitis, providing smoother breathing and symptom control. It assists in managing nighttime asthma attacks and early morning wheezing. Theophylline also aids in controlling preterm infant apnea by increasing respiratory drive.

Ingredients
Theophylline 400 mg.

Uses and Doses
Contine 400 is intended for acute asthma attacks, chronic asthma maintenance, nighttime asthma symptom control, and chronic obstructive pulmonary disease exacerbations.

• Adults: Starting dose is generally 300-400 mg daily, increasing up to 600 mg as needed and tolerated.
• Children: Dosages vary based on age and weight, typically between 10–24 mg/kg/day.
• Precautionary Guidelines: Dose adjustments are recommended based on peak serum theophylline levels to achieve the best results with minimal side effects.

Side Effects
Side effects are infrequent at standard doses, but possible reactions include gastrointestinal discomfort, headache, nausea, hypotension, and increased urination. Higher doses may lead to central nervous system and cardiovascular effects like restlessness, insomnia, and palpitations.

How to Use
Contine 400 tablets can be taken with or without food, ideally an hour before or two hours after meals to ensure maximum absorption. Dosages should be adjusted based on individual serum theophylline levels for optimal benefit.

Pregnancy & Lactation
Theophylline should only be administered to pregnant women when necessary, as effects on the fetus are not fully known. Nursing mothers should also use caution, as theophylline passes into breast milk and may cause mild irritability or toxicity in infants.

Precautions and Warnings
Theophylline doses must be adjusted cautiously, especially in those with hepatic impairment, peptic ulcers, epilepsy, heart disease, or children. Elderly patients and individuals with compromised liver or kidney function should use reduced doses.

Safety Information
Avoid concurrent use with other xanthine derivatives. Careful monitoring is necessary when combined with medications like barbiturates, rifampicin, or phenytoin, which can alter theophylline clearance rates.

Indications
Contine 400 is indicated for asthma, COPD, bronchospasm management, and apnea in premature infants.

Pharmacology
Theophylline, classified under methylxanthines, helps by relaxing bronchial smooth muscle and reducing airway responsiveness. It enhances diaphragm muscle contraction strength, making it effective in respiratory conditions with reversible blockage.

Therapeutic Class
Bronchodilator, Theophylline & related drugs.

Storage Conditions
Store in a cool, dry place, away from direct light, and keep out of reach of children.

3 FAQ

1. Can Contine 400 be taken with food?
   It can be taken with or without food, though ideally, it's taken one hour before or two hours after meals.
2. What is the maximum dosage for adults?
   The maximum dosage should not exceed 900 mg/day.
3. Is it safe during breastfeeding?
   Theophylline is present in breast milk, so nursing mothers should consult their physician for guidance.

Disclaimer
This is general information only. Always consult your doctor or healthcare provider to determine the right dosage and usage for your condition.

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