Generic

Metformin Hydrochloride 500 mg is the active ingredient in Comet XR 500, a widely used medication for managing type 2 diabetes mellitus.

Description

Comet XR 500 contains Metformin Hydrochloride, an antihyperglycemic medication. It helps control blood sugar levels in individuals with type 2 diabetes, especially those who are overweight, by reducing glucose production in the liver and enhancing insulin sensitivity.

Benefits

• Helps manage type 2 diabetes in overweight adults.
• Lowers both fasting and postprandial blood glucose levels.
• Reduces diabetic complications when used as a first-line treatment.
• Can be used with other oral antidiabetics or insulin for enhanced glycemic control.

Ingredients

The active ingredient is Metformin Hydrochloride 500 mg.

Uses and Doses

Comet XR 500 is indicated for treating type 2 diabetes in adults and children over 10 years old.

• Adults: The starting dose is 500 mg twice daily, up to a maximum of 2000 mg daily.
• Children: The starting dose is 500 mg twice daily, with gradual increases.
• For extended-release tablets, take 500 mg once daily with meals.

Side Effects

Common side effects include gastrointestinal discomfort such as nausea, vomiting, and diarrhea. Rare but serious effects include lactic acidosis, vitamin B12 deficiency, and hypoglycemia when used with insulin.

How to Use

Take Comet XR 500 with meals to minimize gastrointestinal side effects. Do not crush or chew the extended-release tablet. Dosage should be gradually increased as tolerated.

Pregnancy & Lactation

Comet XR 500 is not recommended during pregnancy; insulin is preferred to avoid fetal complications. It is secreted in breast milk, so breastfeeding mothers should consult their doctor before use.

Precautions and Warnings

Patients with renal impairment (eGFR below 30 mL/min) should not use Comet XR 500. It may reduce vitamin B12 levels and increase the risk of hypoglycemia when used with insulin.

Safety Information

Avoid alcohol while taking Comet XR 500 as it can increase the risk of lactic acidosis. Monitor kidney function regularly during treatment.

Indications

Comet XR 500 is indicated for managing type 2 diabetes mellitus, especially in overweight individuals when diet and exercise alone do not provide adequate glycemic control.

Pharmacology

Metformin lowers glucose production in the liver, enhances glucose uptake in peripheral tissues, and increases insulin sensitivity without causing hypoglycemia.

Therapeutic Class

Biguanides

Storage Conditions

Store below 30°C in a cool, dry place away from direct light. Keep out of reach of children.

3 FAQ

1. What is the primary use of Comet XR 500?
   Comet XR 500 is used to manage type 2 diabetes, especially in overweight patients.
2. Can children use Comet XR 500?
   Yes, children above 10 years old can use it under medical supervision.
3. What is the maximum daily dose for adults?
   The maximum daily dose is 2000 mg, taken in divided doses.

Disclaimer

The information provided is for general informational purposes only. Consult your healthcare provider for personalized advice.

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