Generic: Zoline 600 ml contains Linezolid, a synthetic antibacterial agent classified as oxazolidinone, primarily used to treat severe bacterial infections caused by Gram-positive bacteria, including multi-drug-resistant strains.

Description: Zoline 600 ml is a prescription antibiotic injection manufactured by IBN SINA Pharmaceutical Industry Ltd. It is a ready-to-use intravenous infusion, formulated to combat serious infections such as vancomycin-resistant Enterococcus faecium and nosocomial pneumonia. It is primarily used in hospitalized patients under medical supervision for bacterial infections.

Benefits: Zoline offers a broad-spectrum antibacterial effect, especially against resistant bacteria like vancomycin-resistant Enterococcus (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). It helps treat complicated skin infections, pneumonia, and other serious bacterial infections, reducing the risk of complications from untreated infections.

Ingredients: The active ingredient in Zoline is Linezolid, present at a concentration of 2 mg/ml. It is formulated for intravenous administration, with other inactive ingredients ensuring the stability and effectiveness of the infusion.

Uses and Doses: Zoline is used to treat:

• Vancomycin-resistant Enterococcus faecium infections.
• Nosocomial pneumonia is caused by Staphylococcus aureus or Streptococcus pneumoniae.
• Complicated and uncomplicated skin infections.
• Community-acquired pneumonia.

The recommended dose for adults is 600 mg IV or oral twice daily for most infections. Pediatric doses vary based on age and infection type.

Side Effects: Common side effects of Zoline include diarrhea, headache, nausea, oral and vaginal moniliasis, hypertension, dyspepsia, and pruritus. More serious side effects may include visual impairment, convulsions, and serotonin syndrome when combined with serotonergic agents.

How to Use: For intravenous administration, Zoline should be infused over 30 to 120 minutes. It should not be used in series connections, and additives must not be mixed with the solution. Oral suspension should be reconstituted with water and shaken well before each use.

Pregnancy & Lactation: Linezolid is classified as a Pregnancy Category C drug. It should be used during pregnancy only when necessary, and its safety in breastfeeding has not been fully established. Caution is advised when administering Zoline to nursing women.

Precautions and Warnings: Zoline should be used with caution in patients with a history of serotonin syndrome or hypertension. Close monitoring is needed when used with other serotonergic drugs. If patients experience vision problems or convulsions, immediate medical attention is required.

Safety Information:

• Zoline should not be used by patients who are hypersensitive to Linezolid or any of its components.
• It should not be used concurrently with monoamine oxidase inhibitors (MAOIs) or certain other medications that could lead to serotonin syndrome or hypertensive crises.
• Regular monitoring is recommended during prolonged use.

Indications: Zoline is indicated for the treatment of:

• Vancomycin-resistant Enterococcus faecium infections.
• Nosocomial pneumonia and complicated skin infections.
• Community-acquired pneumonia, including cases with bacteremia.

Pharmacology: Linezolid works by inhibiting bacterial protein synthesis. It binds to the 23S ribosomal RNA of the bacterial ribosome, preventing the formation of a functional initiation complex, which is essential for bacterial translation. It is bacteriostatic for most enterococci and staphylococci, and bactericidal for most streptococci.

Therapeutic Class: Zoline belongs to the therapeutic class of macrolides, a group of antibiotics used to treat a wide range of bacterial infections.

Storage Conditions: Zoline should be stored at room temperature (15°C-30°C), away from light and moisture. The product should be kept tightly closed and out of reach of children. The oral suspension should be used within 21 days of reconstitution.

FAQ:

1. How is Zoline administered? Zoline is administered via intravenous infusion for 30 to 120 minutes.
2. Can Zoline be used for children? Yes, the dosage for pediatric patients is based on age and condition, with specific guidelines for different age groups.
3. Is Zoline safe during pregnancy? Linezolid is classified as Pregnancy Category C, meaning it should only be used during pregnancy if the potential benefit outweighs the risks.

Disclaimer: Always use Zoline as prescribed by your healthcare provider. This medication is only available with a prescription, and the correct dosage and administration should be followed as per medical guidelines.

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