Generic:
Linezolid 400mg

Description:
Zoline 400 is an antibiotic medication produced by IBN SINA Pharmaceutical Industry Ltd. It is used to treat severe bacterial infections such as pneumonia, skin infections, and infections caused by drug-resistant bacteria. Zoline 400 contains Linezolid, a synthetic antibacterial agent, which belongs to the oxazolidinones class. The tablet works by inhibiting the growth of bacteria, making it effective against a range of Gram-positive and certain Gram-negative bacteria.

Benefits:

• Treats a variety of bacterial infections, including pneumonia and skin infections
• Effective against drug-resistant bacteria, including MRSA and VRE
• Can be used in cases of bacteremia
• Suitable for both adults and children with specific dosing

Ingredients:

• Active Ingredient: Linezolid 400mg
• Excipients: As per formulation

Uses and Doses:
Zoline 400 is used to treat complicated and uncomplicated bacterial infections, including skin infections, community-acquired pneumonia, and nosocomial pneumonia. The typical dosage for adults is 400-600mg twice a day, depending on the condition being treated. Pediatric patients receive weight-based dosing. Always follow your doctor's instructions regarding the dosage and duration of treatment.

Side Effects:
Common side effects of Zoline 400 include headache, nausea, vomiting, diarrhea, and decreased blood cell counts. Other potential side effects are dizziness, rash, and gastrointestinal discomfort. In rare cases, it can cause more serious effects like serotonin syndrome or visual impairment.

How to Use:
Take Zoline 400 orally, with or without food, as directed by your doctor. Swallow the tablet whole with a glass of water. Take it at the same time each day for the best results. Do not stop taking it early, even if you feel better, as the infection may return.

Pregnancy & Lactation:
Zoline 400 falls under Pregnancy Category C. There are no adequate studies on pregnant women, so it should only be used if the potential benefit outweighs the risk to the fetus. It is unknown if Linezolid is excreted in breast milk, so caution is advised for breastfeeding mothers.

Precautions and Warnings:
Patients with pre-existing myelosuppression, renal impairment, uncontrolled hypertension, or a history of seizures should use Zoline 400 cautiously. Monitor blood counts regularly, especially with prolonged use. Avoid consumption of foods rich in tyramine, such as cheese and processed meats, while on this medication.

Safety Information:

• Do not take Zoline 400 if you are allergic to Linezolid or its components.
• Avoid using it with monoamine oxidase inhibitors (MAOIs) or serotonergic agents.
• Do not take for more than 14 days without consulting your doctor.

Indications:
Zoline 400 is indicated for treating community-acquired pneumonia, nosocomial pneumonia, and skin and soft tissue infections. It is also used for vancomycin-resistant Enterococcus faecium infections, including cases with bacteremia.

Pharmacology:
Linezolid inhibits bacterial protein synthesis by binding to the 23S ribosomal RNA of the 50S subunit, preventing the formation of a functional 70S initiation complex. This action halts bacterial growth, making it bacteriostatic against staphylococci and enterococci, and bactericidal against most streptococci.

Therapeutic Class:
Macrolides

Storage Conditions:
Store Zoline 400 at room temperature (15°C-30°C), away from moisture and light. Keep out of reach of children.

3 FAQ:

1. Can I stop taking Zoline 400 if I feel better?
   No, complete the full course of treatment as prescribed to prevent the return or worsening of infection.
2. Are there any food restrictions while taking Zoline 400?
   Yes, avoid tyramine-rich foods like cheese, processed meats, and certain alcoholic beverages.
3. Is Zoline 400 safe during pregnancy?
   Zoline 400 should only be used during pregnancy if the potential benefits outweigh the risks. Consult your doctor.

Disclaimer:
This information is intended for general informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read here.

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