Generic:
Pregabalin 82.5 mg (Xil-CR 82.5 Tablet - Controlled Release) by Orion Pharma Ltd.

Description:
Xil-CR 82.5 is a controlled-release medication primarily used to treat neuropathic pain and other neurological conditions. It belongs to the anti-epileptic drug class and is effective in reducing nerve pain from diabetes, shingles, and spinal cord injury. It also helps manage seizures and fibromyalgia.

Benefits:
Xil-CR 82.5 effectively treats nerve-related pain and certain types of seizures. It is also beneficial for managing fibromyalgia and related muscle pain. The controlled-release formulation ensures a prolonged therapeutic effect.

Ingredients:
Pregabalin 82.5 mg

Uses and Doses:

• Neuropathic pain (DPN): Start with 50 mg thrice daily (150 mg/day). Increase to 300 mg/day within a week based on patient response.
• Postherpetic neuralgia (PHN): Start with 75-150 mg twice daily, and increase as necessary to 300 mg/day within a week.
• Fibromyalgia: Start with 75 mg twice daily, increase to 300-450 mg/day as tolerated.
• Seizures and spinal cord injury-related pain: Dosing starts at 75 mg twice daily, with a maximum of 600 mg/day based on tolerance.

Side Effects:
Common side effects include dizziness, somnolence, dry mouth, blurred vision, weight gain, and difficulty concentrating. In rare cases, it may cause angioedema, increased appetite, or suicidal thoughts.

How to Use:
Xil-CR 82.5 is taken orally, preferably after an evening meal. It should be swallowed whole, not split or crushed. If a dose is missed, take it before bedtime or the next morning after a snack.

Pregnancy & Lactation:
There are no well-controlled studies on the use of pregabalin in pregnant women. Pregnant women should be informed about potential risks. Pregabalin may pass into breast milk, so it is not recommended for breastfeeding.

Precautions and Warnings:
Discontinue immediately if symptoms of angioedema or hypersensitivity occur. Xil-CR 82.5 can increase the risk of suicidal thoughts, and patients must be monitored. Avoid abrupt discontinuation, as it can lead to withdrawal symptoms.

Safety Information:
Xil-CR may impair the ability to operate machinery or drive. It should not be taken with alcohol or other CNS depressants, as these can exacerbate drowsiness.

Indications:

• Neuropathic pain (DPN and PHN)
• Fibromyalgia
• Adjunctive therapy for partial seizures
• Neuropathic pain associated with spinal cord injury

Pharmacology:
Pregabalin, a derivative of GABA, binds to the alpha2-delta site of voltage-gated calcium channels in the CNS, potentially contributing to its anti-nociceptive and antiseizure effects.

Therapeutic Class:
Anti-epileptic drugs

Storage Conditions:
Store below 30°C, in a cool, dry place away from light and moisture. Keep out of reach of children.

3 FAQ:

• How long does it take for Xil-CR 82.5 to work? Improvement may take a few weeks, depending on the condition.
• Can I drive after taking Xil-CR 82.5? Xil-CR may cause drowsiness and dizziness, so avoid driving until you know how it affects you.
• What should I do if I miss a dose? Take the missed dose before bedtime or after a morning meal. Never double the dose.

Disclaimer:
This information is for reference only. Always consult a healthcare provider before using any medication.

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