Generic Name: Voriconazole 200mg

Description: Vori 200 is an antifungal medication formulated to combat a broad spectrum of severe fungal infections. It works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting cell growth and replication.

Benefits:

• Effectively treats severe fungal infections such as invasive aspergillosis and candidemia.
• Provides a therapeutic option for patients intolerant to other treatments.
• Suitable for treating infections caused by Scedosporium apiospermum and Fusarium species.

Ingredients: Active Ingredient: Voriconazole 200mg.
Excipients: [Specific inactive ingredients would typically be listed here, but are not provided in the given information].

Uses and Doses:

• Adults and Children Over 12 Years:
  • Oral Tablets/Suspension: Take 400 mg every 12 hours on the first day, followed by 200 mg every 12 hours as a maintenance dose.
  • Intravenous (IV): For invasive aspergillosis, initiate with 6 mg/kg every 12 hours for the first 24 hours, followed by 4 mg/kg every 12 hours.
• Children Under 12 Years: Safety and efficacy not established.
• Special Populations: Dosage adjustments may be required for patients with hepatic or renal impairments.

Side Effects: Common side effects include visual disturbances (such as blurred vision or photophobia), nausea, headache, rash, and abnormal liver function tests. Serious adverse reactions may involve hallucinations, slow heart rate, or severe allergic responses.

How to Use: Take Vori 200 on an empty stomach, either one hour before or after a meal. Swallow the tablet whole without crushing or chewing. For the IV form, it should be administered over 1-2 hours. Continue the prescribed course even if symptoms improve early.

Pregnancy & Lactation: There are no sufficient well-controlled studies in pregnant women. Vori 200 should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. It is unknown if Voriconazole is excreted in human breast milk, so a decision should be made to discontinue nursing or the drug based on its importance to the mother.

Precautions and Warnings: Long-term use exceeding 180 days requires careful consideration due to the risk of squamous cell carcinoma. Monitor liver function tests before and during treatment. Patients with potentially proarrhythmic conditions, renal or hepatic impairment, or those requiring concurrent medications should consult their doctor for tailored advice.

Safety Information:

• Do not take Vori 200 if allergic to Voriconazole or any of its components.
• Avoid co-administration with specific drugs due to serious interaction risks (e.g., terfenadine, cisapride, and certain barbiturates).
• Be cautious about driving or operating machinery as Vori 200 may cause dizziness or visual disturbances.
• Protect yourself from prolonged exposure to sunlight as this medication can increase skin sensitivity.

Indications: Vori 200 is indicated for treating serious fungal infections in adults and children aged 12 and over, including:

• Invasive aspergillosis
• Candidemia in non-neutropenic patients
• Severe infections by Scedosporium and Fusarium species

Pharmacology: Voriconazole, a triazole antifungal, works by inhibiting the enzyme CYP450-dependent 14-alpha sterol demethylase. This enzyme is critical in the synthesis of ergosterol, a fundamental component of the fungal cell membrane. The inhibition leads to impaired cell membrane function and growth of the fungi.

Therapeutic Class: Other Antifungal Preparations

Storage Conditions: Store below 25°C in a cool, dry place away from light and moisture. Keep out of reach of children.

Frequently Asked Questions (FAQ)

1. What is Vori 200 used for? Vori 200 is used to treat severe fungal infections such as invasive aspergillosis, candidemia, and infections caused by Fusarium species.

2. Can I take Vori 200 with food? Vori 200 should be taken on an empty stomach, either one hour before or after meals.

3. What should I do if I miss a dose? Take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

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