Generic

U4 combines Flupentixol (0.5mg) and Melitracen (10mg), forming a synergistic blend to treat depression and anxiety disorders. This dual-action formula is designed to balance mood and alleviate symptoms of depression and anxiety by modulating neurotransmitter activity in the brain.

Description

U4 is a medication produced by Orion Pharma Ltd., containing the active ingredients Flupentixol and Melitracen. This tablet is used to manage depression and anxiety by enhancing neurotransmitter function, providing both antidepressant and anxiolytic effects. It is especially beneficial in conditions involving apathy and psychosomatic symptoms.

Benefits

U4 effectively treats various forms of depression and anxiety, including psychogenic and menopausal depression. It helps in alleviating symptoms such as restlessness, apathy, and dysphoria. By combining a neuroleptic and a tricyclic antidepressant, it offers comprehensive mood stabilization and improves the overall quality of life for patients.

Ingredients

The primary ingredients in U4 are Flupentixol, a thioxanthene antipsychotic (0.5mg), and Melitracen, a tricyclic antidepressant (10mg). This combination works synergistically to provide both antidepressant and anxiolytic effects, optimizing neurotransmitter activity in the brain.

Uses and Doses

U4 is prescribed for managing depression, anxiety, and associated conditions. Adults typically take 2 tablets daily, in the morning and at noon. In severe cases, the morning dose may be increased to 2 tablets. Elderly patients usually take 1 tablet in the morning. A maintenance dose of 1 tablet in the morning is recommended. In cases of insomnia or severe restlessness, additional sedative treatment may be required.

Side Effects

Common side effects of U4 include dry mouth, constipation, urinary retention, blurred vision, increased heart rate, and muscle rigidity. Other potential effects are restlessness and tremors. It's important to monitor for any sudden changes in mood or symptoms, and to consult with a doctor if adverse effects are experienced.

How to Use

Take U4 as prescribed by your doctor. Swallow the tablets whole with water, preferably at the same time each day to maintain consistent blood levels. Do not crush or chew the tablets. U4 can be taken with or without food. If you miss a dose, take it as soon as you remember, unless it is close to your next scheduled dose.

Pregnancy & Lactation

U4 should be used with caution during pregnancy and lactation. It is generally advised to avoid this medication unless absolutely necessary, as it may pose risks to the developing fetus or nursing infant. Always consult a healthcare provider before starting or continuing this medication during pregnancy or breastfeeding.

Precautions and Warnings

Patients with a history of myocardial infarction, untreated narrow-angle glaucoma, or recent MAO inhibitor use should avoid U4. It's crucial to gradually taper off sedative tranquilizers before starting this medication. Those with excitable or overactive tendencies should use caution, as U4 may amplify these characteristics.

Safety Information

U4 can interact with alcohol, CNS depressants, and other medications, potentially enhancing their effects. Avoid combining U4 with MAO inhibitors or substances that influence blood pressure or heart function without consulting a doctor. Regular monitoring by a healthcare provider is recommended to manage potential interactions and side effects.

Indications

U4 is indicated for treating various forms of depression and anxiety, including psychogenic depression, depressive neuroses, and menopausal depression. It is also effective for managing psychosomatic conditions accompanied by anxiety and apathy, as well as dysphoria in alcoholics and drug addicts.

Pharmacology

U4 combines Flupentixol and Melitracen to provide antidepressant and anxiolytic effects. Flupentixol acts as a neuroleptic by blocking dopamine receptors, while Melitracen, a tricyclic antidepressant, increases the levels of mood-regulating neurotransmitters. Together, they reach peak blood concentrations in about 4 hours and have half-lives of 35 and 19 hours, respectively.

Therapeutic Class

U4 belongs to the therapeutic class of combined anxiolytics and antidepressant drugs. This classification underscores its dual action in treating both anxiety and depressive disorders by modulating neurotransmitter activity in the brain.

Storage Conditions

Store U4 in a dry, cool place with a temperature not exceeding 30°C. Protect the tablets from light and moisture. Keep out of reach of children to prevent accidental ingestion.

FAQ

1. What conditions does U4 treat? U4 is used to treat various types of depression and anxiety, including psychogenic and menopausal depression, as well as dysphoria in alcoholics and drug addicts.
2. How should I take U4? Take U4 as prescribed by your doctor, usually 2 tablets daily in the morning and at noon. Swallow the tablets whole with water, and try to take them at the same time each day.
3. Can I take U4 during pregnancy? U4 is not recommended during pregnancy unless necessary. Consult your healthcare provider before starting or continuing this medication if you are pregnant or breastfeeding.

Disclaimer

The information provided here is for informational purposes only and should not replace professional medical advice. Always consult your doctor or a qualified healthcare provider for any medical concerns or conditions. Do not delay seeking professional medical advice based on this information.

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