Generic
Sergel 20, a generic form of Esomeprazole Magnesium Trihydrate, is a proton pump inhibitor used to reduce stomach acid production.

Description
Sergel 20 is a medication prescribed for the treatment of GERD, peptic ulcer disease, and other conditions caused by excess stomach acid. It works by inhibiting the enzyme responsible for acid secretion in the stomach, providing relief from heartburn and preventing the recurrence of ulcers.

Benefits
Sergel 20 helps in reducing chronic heartburn, treating peptic ulcers, and preventing acid-related damage in the digestive tract. It also aids in the treatment of Helicobacter pylori infection and prevents gastric ulcers.

Ingredients
Each capsule contains 20mg of Esomeprazole Magnesium Trihydrate, formulated as enteric-coated pellets for delayed release.

Uses and Doses
Sergel 20 is indicated for the treatment of GERD, erosive esophagitis, duodenal and gastric ulcers, Helicobacter pylori infection, Zollinger-Ellison Syndrome, and acid-related dyspepsia. The usual dose is 20mg to 40mg once daily, depending on the condition, taken one hour before meals.

Side Effects
Common side effects include headache, nausea, abdominal pain, diarrhea, constipation, dry mouth, and flatulence. Rarely, serious side effects such as kidney issues, low magnesium levels, and bone fractures may occur with long-term use.

How to Use
Swallow the capsule whole, at least one hour before a meal. If you have trouble swallowing, you can open the capsule and sprinkle the contents on applesauce. Do not chew or crush the pellets.

Pregnancy & Lactation
There are no well-controlled studies on the use of esomeprazole in pregnant women. Esomeprazole may be present in human milk, so breastfeeding should be avoided if the medication is deemed necessary.

Precautions and Warnings
Sergel 20 may mask the symptoms of stomach cancer. Long-term use can lead to magnesium deficiency and increase the risk of bone fractures. Consult your doctor if symptoms persist, and avoid taking other acid-lowering medications simultaneously.

Safety Information
Store at a temperature not exceeding 30°C, away from direct sunlight and moisture. Keep out of reach of children.

Indications
Sergel 20 is indicated for treating GERD, erosive esophagitis, peptic ulcers, Helicobacter pylori infection, and Zollinger-Ellison syndrome.

Pharmacology
Esomeprazole, the active ingredient in Sergel 20, inhibits the H+/K+-ATPase enzyme in gastric parietal cells, reducing acid production. It is metabolized in the liver by the cytochrome P450 enzyme system and is highly protein-bound.

Therapeutic Class
Proton Pump Inhibitor

Storage Conditions
Store in a cool, dry place, below 30°C. Protect from direct sunlight and moisture.

3 FAQ

1. Can I take Sergel 20 with food?
   No, it should be taken at least one hour before meals.
2. How long should I take Sergel 20?
   Your doctor will determine the duration, but it may take up to a few weeks to work properly.
3. Can I crush or chew the capsule?
   No, the capsule should be swallowed whole or mixed with applesauce if needed.

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