Generic
Clopidogrel 75mg, Aspirin 75mg

Description
Plagrin Plus Tablet is a combination of Clopidogrel and Aspirin, primarily used to reduce the risk of heart attack and stroke in patients with acute coronary syndrome (ACS). This antiplatelet medication works by preventing blood clot formation, ensuring smooth blood flow in patients with a high cardiovascular risk profile.

Benefits
Plagrin Plus lowers the risk of myocardial infarction and stroke in patients with heart disease. It offers dual action, preventing clot formation and reducing artery blockages, providing long-term cardiovascular protection.

Ingredients
Active ingredients: Clopidogrel 75mg, Aspirin 75mg.

Uses and Doses
Plagrin Plus is used to reduce the risk of heart attacks and strokes in patients with ACS, recent MI, stroke, or confirmed peripheral artery disease. The recommended dosage is one tablet daily, as prescribed by a physician.

Side Effects
Common side effects include bleeding, diarrhea, gastrointestinal discomfort, and skin reactions. Rare side effects may include anemia, angioedema, joint pain, and bone marrow disease.

How to Use
Take one tablet daily with or without food. Follow your doctor's instructions for dosage and timing. Avoid missing doses, and do not double the dosage if one is missed.

Pregnancy & Lactation
Plagrin Plus should only be used during pregnancy if clearly necessary, as there is no adequate research on its safety for pregnant women. It is not known whether the drug is excreted in breast milk, so consult a doctor before use during breastfeeding.

Precautions and Warnings
Patients with a history of allergies to Clopidogrel or Aspirin should avoid using Plagrin Plus. It may increase the risk of bleeding, especially if taken alongside NSAIDs or anticoagulants. Discontinue 5 days prior to surgery to avoid severe bleeding.

Safety Information
Ensure to avoid any potential drug interactions, particularly with omeprazole or esomeprazole, as these may reduce the effectiveness of Clopidogrel. Watch for any signs of bleeding or allergic reactions and consult a doctor if needed.

Indications
Plagrin Plus is indicated for patients with ACS, recent myocardial infarction, recent stroke, or confirmed peripheral artery disease to reduce the risk of heart attacks and strokes.

Pharmacology
Clopidogrel inhibits platelet activation by irreversibly binding to the P2Y12 ADP receptors on platelets. Aspirin further inhibits platelet aggregation, providing a comprehensive solution to reducing blood clot formation. The steady antiplatelet effect occurs within 3-7 days of administration.

Therapeutic Class
Anti-platelet drugs

Storage Conditions
Store below 30°C in a dry place, protected from light. Do not freeze. Keep out of the reach of children.

3 FAQ

1. Can I take Plagrin Plus with other painkillers?
   It is recommended to avoid NSAIDs while on Plagrin Plus as it increases the risk of bleeding. Consult your doctor before combining medications.
2. What should I do if I miss a dose?
   Take the missed dose as soon as possible unless it is near the time for your next dose. Do not double the dose to catch up.
3. How long does it take for Plagrin Plus to show its effect?
   The drug starts showing platelet inhibition within 2 hours, with maximum effect achieved between 3 to 7 days of continuous use.

Disclaimer
This information is provided for general informational purposes and should not replace professional medical advice. Always consult your healthcare provider before starting any medication.

Keywords: Plagrin Plus, Clopidogrel, Aspirin, heart attack prevention, stroke prevention, antiplatelet drug, ACS treatment, cardiovascular health, Renata Pharma, myocardial infarction, stroke, platelet aggregation inhibitor, Clopidogrel 75mg, Aspirin 75mg, heart medication, blood thinner, stroke risk reduction, heart health, STEMI treatment, NSTEMI treatment.