Generic
Clopidogrel Bisulphate

Description
Plagrin 75 is an antiplatelet medication used to prevent the formation of blood clots, reducing the risk of heart attack or stroke. It is formulated with Clopidogrel Bisulphate and helps in conditions such as Acute Coronary Syndrome (ACS) and peripheral artery disease. Manufactured by Renata Pharma Ltd, it is a well-regarded option for cardiovascular health.

Benefits

• Reduces the risk of heart attack and stroke.
• Inhibits platelet aggregation to prevent clot formation.
• Effective in treating patients with ACS, recent myocardial infarction, or established peripheral artery disease.
• Convenient daily dosage with or without food.

Ingredients
Active Ingredient: Clopidogrel Bisulphate 75mg

Uses and Doses

• Acute Coronary Syndrome (ACS): Initial dose of 300 mg (4 tablets) followed by 75 mg once daily.
• Recent Myocardial Infarction (MI), stroke, or peripheral artery disease: 75 mg once daily, with or without food.

Side Effects
Common side effects include bleeding, gastrointestinal distress, and skin reactions. Rare side effects may include hemophilia, weakness, and bone marrow disorders.

How to Use
Take the tablet orally with or without food, following your doctor’s instructions. If an antiplatelet effect is required quickly, start with a loading dose of 300 mg followed by 75 mg daily.

Pregnancy & Lactation
Clopidogrel should only be used during pregnancy if needed. Its presence in human breast milk is unknown, so a decision should be made to either discontinue the drug or stop nursing.

Precautions and Warnings
Patients with poor CYP2C19 metabolizers or those taking inhibitors like Omeprazole may experience reduced effectiveness. Due to its platelet inhibition, there is a higher risk of bleeding, particularly during surgeries. Thrombotic Thrombocytopenic Purpura (TTP) has been reported, requiring urgent treatment.

Safety Information
Keep the product in a cool, dry place below 30°C. Avoid exposure to direct light and ensure it is stored out of the reach of children.

Indications

• Acute Coronary Syndrome (ACS)
• Recent myocardial infarction or stroke
• Established peripheral arterial disease

Pharmacology
Clopidogrel is a prodrug that inhibits platelet activation by binding to the P2Y12 ADP receptors. Its antiplatelet effects start within 2 hours of dosing, reaching a steady state between Day 3 and Day 7.

Therapeutic Class
Anti-platelet drugs

Storage Conditions
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.

3 FAQ

1. Is Plagrin safe for long-term use?
   Yes, but long-term use may increase the risk of bleeding. Follow your doctor’s advice closely.
2. Can I take Plagrin with food?
   Yes, it can be taken with or without food.
3. What should I do if I miss a dose?
   Take it as soon as you remember, but skip it if it's near the time for your next dose. Do not double the dose.

Disclaimer
This information is for general knowledge only and should not replace medical advice. Always consult a healthcare professional before starting any new medication.

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