Generic

Obeticholic Acid

Description

Obeticholic Acid is a medication used primarily for the treatment of primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) or as a monotherapy in cases where UDCA is not tolerated.

Benefits

• Reduces liver inflammation and fibrosis in PBC patients.
• Helps manage liver conditions by regulating bile acid synthesis and transport.
• May provide benefits in cholestatic liver diseases and non-alcoholic fatty liver disease (NAFLD).

Ingredients

Active Ingredient: Obeticholic Acid Inactive Components: [List specific excipients if available]

Uses and Doses

Starting dosage is 5 mg orally once daily, increasing to 10 mg if necessary after three months based on patient response and tolerability.

Side Effects

Common side effects include pruritus, fatigue, abdominal pain, and discomfort. Other effects can include rash, oropharyngeal pain, and dizziness.

How to Use

Take orally with or without food. If using bile-acid binding resins, dose obeticholic acid at least 4 hours before or after these agents.

Pregnancy & Lactation

The effects of Obeticholic Acid during pregnancy are unclear due to limited human data. It is unknown if it is present in breast milk.

Precautions and Warnings

Monitor for liver enzyme elevations and signs of hepatic decompensation. Special caution is advised for patients with advanced liver disease.

Safety Information

Avoid use in patients with complete biliary obstruction or known hypersensitivity to the medication.

Indications

Used for treating PBC, cholestatic liver diseases, and NAFLD, particularly in patients who do not respond adequately to UDCA.

Pharmacology

Obeticholic Acid functions as an agonist of the Farnesoid X receptor (FXR), which is involved in the regulation of bile acid, inflammatory, fibrotic, and metabolic pathways.

Therapeutic Class

Farnesoid X Receptor Agonists.

Storage Conditions

Store at temperatures between 15°C to 30°C in a dry place protected from light. Keep out of reach of children.

3 FAQ

1. What should I do if I experience severe side effects from Obeticholic Acid?
2. Can Obeticholic Acid be used during pregnancy?
3. How should Obeticholic Acid be taken in relation to other medications?

Disclaimer

Information regarding Obeticholic Acid is provided for educational purposes only and is not intended as medical advice. Always consult a healthcare provider for treatment options.

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