Generic

Neso 375 combines Naproxen Sodium 375mg and Esomeprazole 20mg, aimed at reducing inflammation and providing gastric protection in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

Description

Neso 375 Tablet is a combination therapy by Aristopharma Ltd. containing Naproxen, a non-steroidal anti-inflammatory drug (NSAID), and Esomeprazole, a proton pump inhibitor. This formulation is crafted to alleviate pain and inflammation associated with arthritis while also minimizing gastric complications from NSAID therapy.

Benefits

Neso 375 provides dual benefits: relief from inflammatory arthritis symptoms and reduction in gastric ulcer risk. Esomeprazole offers gastric protection, making this tablet ideal for long-term NSAID users susceptible to stomach issues.

Ingredients

• Naproxen Sodium: 375 mg
• Esomeprazole Magnesium: 20 mg

Uses and Doses

For osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis:

• Adults: One tablet twice daily (375 mg Naproxen/20 mg Esomeprazole).
• Adolescents 12 years and older (≥50 kg): 375 mg/20 mg tablet twice daily. Do not split, chew, or dissolve the tablet. Take at least 30 minutes before meals.

Side Effects

This formulation is generally well-tolerated, though common side effects may include gastritis, dyspepsia, gastric ulcer, nausea, and diarrhea.

How to Use

Take the tablet as directed by your physician, swallowing it whole with water at least 30 minutes before a meal. Do not crush or chew the tablet.

Pregnancy & Lactation

Classified as Pregnancy Category C, this medication is not advised for use in the third trimester due to potential risks to fetal heart development. Breastfeeding mothers should avoid use due to Naproxen content.

Precautions and Warnings

Use cautiously if you have a history of cardiovascular disease, fluid retention, or heart failure. Avoid if allergic to any of its components or if you have a history of asthma triggered by NSAIDs.

Safety Information

• Keep out of reach of children.
• Do not use if allergic to any ingredients.
• Avoid in cases of aspirin or NSAID-related asthma or urticaria.

Indications

This combination is indicated for managing symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It also reduces the risk of NSAID-related gastric ulcers.

Pharmacology

Neso 375 features a dual-layer release mechanism where Esomeprazole is immediately released in the stomach to protect the lining, followed by a delayed release of Naproxen in the intestine to ensure targeted anti-inflammatory action.

Therapeutic Class

Classified under Drugs for Osteoarthritis, NSAIDs, and Rheumatoid Arthritis treatments.

Storage Conditions

Store at temperatures below 30°C, protected from light and moisture. Keep out of reach of children.

FAQs

1. Can Neso 375 be taken with other NSAIDs?
Avoid using Neso 375 with other NSAIDs as this may increase the risk of adverse side effects.

2. Is Neso 375 safe for long-term use?
While effective, long-term use should be monitored by a healthcare provider due to cardiovascular and gastric risks.

3. What should I do if I miss a dose?
Take the missed dose as soon as possible unless it's close to the next dose. Do not double the dose.

Disclaimer

This information is for educational purposes only and should not substitute professional medical advice. Always consult your physician or pharmacist for specific health concerns.

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