Generic
Napro-A Plus 500 is a combination medication containing Naproxen Sodium and Esomeprazole Magnesium. It’s primarily used to relieve pain and inflammation from osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other conditions.

Description
This tablet combines Naproxen, an NSAID effective in reducing inflammation and pain, with Esomeprazole, a proton-pump inhibitor that reduces stomach acid to protect against gastric ulcers associated with NSAID use. The unique formulation ensures that Esomeprazole releases quickly in the stomach while Naproxen dissolves in the intestine.

Benefits
Napro-A Plus 500 offers dual benefits by alleviating pain and inflammation and reducing the risk of NSAID-related gastric ulcers, making it ideal for individuals with joint pain and sensitive stomachs.

Ingredients

• Naproxen Sodium 500 mg
• Esomeprazole Magnesium 20 mg

Uses and Doses
Napro-A Plus 500 is commonly prescribed for osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. For adults, the standard dose is one tablet (either 375 mg or 500 mg Naproxen / 20 mg Esomeprazole) taken twice daily. Adolescents above 12 years and weighing over 38 kg may also take this tablet under medical guidance.

Side Effects
Common side effects include nausea, vomiting, headache, diarrhea, indigestion, flatulence, and stomach pain. In clinical trials, more than 5% of users reported symptoms like erosive gastritis and dyspepsia.

How to Use
Take the tablet in the dose and duration as advised by your doctor. Swallow whole with food to prevent stomach upset, and avoid chewing, crushing, or breaking it.

Pregnancy & Lactation
This medication is classified as Category C for pregnancy. It is advised to avoid usage in the late stages of pregnancy as it may lead to premature closure of the ductus arteriosus. Nursing mothers should also avoid this medication due to the Naproxen component.

Precautions and Warnings
Patients with cardiovascular conditions or risk factors should use Napro-A Plus 500 cautiously. Those with fluid retention or heart failure should consult a doctor before starting this medication.

Safety Information
Store in a dry, cool place, away from children and direct sunlight. Do not exceed the prescribed dose and avoid alcohol while taking this medication.

Indications
The medication is indicated for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and the prevention of NSAID-induced gastric ulcers in at-risk patients.

Pharmacology
Napro-A Plus 500 utilizes an enteric-coated Naproxen core and an outer Esomeprazole coating. Naproxen reduces pain and inflammation by inhibiting prostaglandin production, while Esomeprazole decreases gastric acidity by blocking the H+/K+ ATPase enzyme in gastric parietal cells.

Therapeutic Class
This medication falls under non-steroidal anti-inflammatory drugs (NSAIDs) and is used to treat osteoarthritis, rheumatoid arthritis, and other similar conditions.

Storage Conditions
Store below 30°C, protected from light and moisture. Keep out of reach of children.

3 FAQ

1. Can I take Napro-A Plus 500 without food?
   It’s recommended to take this medication with food to avoid stomach upset.
2. Can pregnant women use this medication?
   It should be avoided during pregnancy, especially in the late stages.
3. What should I do if I miss a dose?
   Take the missed dose as soon as you remember, but skip it if it’s nearly time for the next dose.

Disclaimer
This is a prescription medication. Always use it under the guidance of a healthcare provider. Seek immediate medical attention if you experience severe side effects.

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