Generic
Nabumetone 750mg is the active ingredient in Nabumet 750, a nonsteroidal anti-inflammatory drug (NSAID) from Eskayef Pharmaceuticals Ltd.

Description
Nabumet 750 is a prescription-based NSAID that helps relieve symptoms associated with osteoarthritis and rheumatoid arthritis, including pain, inflammation, and stiffness. It contains 750mg of Nabumetone, a prodrug activated in the liver to provide anti-inflammatory and analgesic effects.

Benefits
Nabumet 750 effectively reduces inflammation and relieves pain associated with arthritis conditions. It helps improve mobility and joint function, enabling patients to manage symptoms more comfortably.

Ingredients
Active Ingredient: Nabumetone 750mg.
Other excipients include stabilizers and binding agents as per pharmaceutical standards.

Uses and Doses
For osteoarthritis and rheumatoid arthritis, the starting dose is 1,000 mg once daily. Depending on the patient's needs, the dose may be increased to 1,500-2,000 mg daily, either in a single or divided dose. However, doses above 2,000 mg are not recommended.

Side Effects
Common side effects include digestive issues like diarrhea, dyspepsia, and stomach discomfort. Other possible effects include dizziness, headache, skin rash, and tinnitus. Edema, nausea, and dry mouth may also occur.

How to Use
Take Nabumet 750 as directed by a physician. It can be taken with or without food. Use the lowest effective dose for the shortest possible time to minimize potential side effects.

Pregnancy & Lactation
Nabumetone is classified as Pregnancy Category C. Limited studies on animals indicate no clear risk, but adequate studies in pregnant women are lacking. It should be used during pregnancy only if necessary. Caution is advised for breastfeeding mothers.

Precautions and Warnings
Nabumet 750 cannot substitute corticosteroids. Patients on long-term corticosteroid therapy should gradually reduce their dosage if discontinuation is desired. Nabumetone may mask fever and inflammation, complicating the diagnosis of certain conditions.

Safety Information
Avoid Nabumet 750 if allergic to NSAIDs or if previous reactions to aspirin have occurred. It is contraindicated for post-CABG surgery pain management.

Indications
Nabumetone is indicated for osteoarthritis and rheumatoid arthritis, focusing on symptomatic relief of pain and inflammation.

Pharmacology
Nabumetone acts as a non-selective COX inhibitor, reducing inflammation by blocking prostaglandin synthesis. It is a prodrug, metabolized in the liver to an active form, 6-methoxy-2-naphthylacetic acid (6MNA).

Therapeutic Class
Classified under drugs for osteoarthritis and rheumatoid arthritis.

Storage Conditions
Store at 25°C in a tightly sealed, light-resistant container. Temporary storage between 15-30°C is permissible.

FAQ

1. Can Nabumet 750 be taken with food?
   Yes, it can be taken with or without food, as your physician advises.
2. What should I do if I miss a dose?
   Take the missed dose as soon as possible, but skip it if it’s near the time for the next dose.
3. Are there any serious side effects I should watch for?
   Serious side effects include difficulty breathing, severe rash, or chest pain. Contact a healthcare provider immediately if any occur.

Disclaimer
This information is provided for educational purposes and should not replace medical advice from a healthcare professional.

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