Generic

Metformin Hydrochloride

Description

Metfo XR 500 is an extended-release formulation of Metformin Hydrochloride designed for once-daily use in managing Type 2 diabetes mellitus. It helps control blood sugar levels by reducing glucose production in the liver, improving insulin sensitivity, and decreasing intestinal glucose absorption. This formulation ensures gradual drug release, improving tolerance and reducing gastrointestinal side effects. It is particularly beneficial for overweight, diabetic individuals.

Benefits

Metfo XR 500 provides steady and prolonged blood sugar control, reducing the risk of hyperglycemia and diabetes complications. Compared to immediate-release formulations, it offers better gastrointestinal tolerance and is preferred for patients requiring once-daily dosing. The extended-release mechanism allows for consistent therapeutic effects throughout the day.

Ingredients

Each Metfo XR 500 tablet contains 500 mg of metformin hydrochloride, an extended-release oral antihyperglycemic agent from the biguanide class.

Uses and Doses

Metfo XR 500 is used to treat Type 2 diabetes mellitus when diet and exercise alone are insufficient. It is suitable for adults and children (10 years and older) and can be used alone or with insulin or other diabetes medications.

• Adults (Extended-Release Tablets):
  • The starting dose is 500mg once daily with an evening meal.
  • Dose adjustments: Increase by 500mg weekly, up to a maximum of 2000mg daily.
  • Alternative dosing: 1000mg twice daily if better glycemic control is needed.
• Children (10 years and older):
  • Not studied for extended-release use.
• Patients with Renal Impairment:
  • Not recommended for eGFR <30 mL/min/1.73m².
  • Use caution if eGFR is 30–45 mL/min/1.73m².

Metfo XR 500 must be swallowed whole and never crushed, cut, or chewed.

Side Effects

Common side effects include nausea, vomiting, diarrhoea, stomach pain, bloating, taste disturbances, and vitamin B12 deficiency. Lactic acidosis is a rare but serious side effect requiring immediate medical attention.

How to Use

Take Metfo XR 500 with your evening meal to ensure gradual drug absorption and reduce gastrointestinal discomfort. Do not break or chew the tablet, as this will disrupt the extended-release mechanism.

Pregnancy & Lactation

• Pregnancy: Poorly controlled diabetes during pregnancy increases the risk of congenital disabilities and perinatal mortality. Insulin is the preferred treatment for pregnant women.
• Breastfeeding: Metformin is excreted in breast milk, but no adverse effects have been reported. However, consultation with a healthcare provider is recommended before using Metfo XR 500 while nursing.

Precautions and Warnings

• Renal Function: Metformin is eliminated via the kidneys, requiring periodic renal function assessment.
• Lactic Acidosis Risk: Avoid use in renal impairment, dehydration, heart failure, liver disease, or conditions leading to tissue hypoxia.
• Vitamin B12 Deficiency: Long-term use may lead to vitamin B12 depletion, requiring monitoring.

Safety Information

Metfo XR 500 is contraindicated in individuals with:

• Severe renal failure (eGFR <30 mL/min/1.73m²).
• Acute metabolic acidosis (e.g., lactic acidosis, diabetic ketoacidosis).
• Severe dehydration, infections, or conditions leading to tissue hypoxia (e.g., heart failure, respiratory failure, or myocardial infarction).
• Liver disease or chronic alcoholism.

Indications

Metfo XR 500 is indicated for:

• First-line treatment of Type 2 diabetes mellitus in adults and children (10 years and older).
• Combination therapy with insulin or other oral diabetes medications.
• Improving glycemic control in overweight diabetic patients.

Pharmacology

Metformin works by:

• Reducing hepatic glucose production.
• Decreasing intestinal glucose absorption.
• Increasing insulin sensitivity in peripheral tissues.

Unlike sulfonylureas, Metformin nn does not cause hypoglycemia when used alone.

Therapeutic Class

Biguanides (Oral Antihyperglycemic Agents).

Storage Conditions

Store below 30°C, protected from light and moisture. Keep out of reach of children.

3 FAQ

Q1: Can Metfo XR 500 be taken in the morning?
Taking Metfo XR 500 with the evening meal is recommended for optimal blood sugar control.

Q2: Is Metfo XR 500 better thanregular metforminn?
Metfo XR 500 has a lower risk of gastrointestinal side effects and provides steady glucose control with once-daily dosing.

Q3: Can Metfo XR 500 be taken with other diabetes medications?
It can be combined with insulin or other oral diabetes medications for better glycemic control.

Disclaimer

This content is for informational purposes only and should not be considered medical advice. Always consult a healthcare professional before starting or adjusting any medication.

 

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