Generic

Losan Plus (Losartan Potassium 50mg + Hydrochlorothiazide 12.5mg) is a combination medication manufactured by Orion Pharma Ltd. It is used primarily to manage high blood pressure and reduce the risk of stroke, particularly in patients with left ventricular hypertrophy.

Description

This medication contains two active ingredients: Losartan Potassium, an angiotensin II receptor antagonist, and Hydrochlorothiazide, a thiazide diuretic. Together, these components help in controlling blood pressure by preventing blood vessel constriction and promoting fluid excretion.

Benefits

• Effectively manages hypertension
• Reduces the risk of stroke in patients with left ventricular hypertrophy
• Helps maintain balanced potassium levels despite diuretic effects
• Offers a combination approach for those who don't respond to monotherapy

Ingredients

• Losartan Potassium: 50mg
• Hydrochlorothiazide: 12.5mg

Uses and Doses

• Hypertension: Starting dose is usually 50/12.5mg once daily. If the blood pressure is not controlled, the dose can be increased to 100/25mg once daily.
• Severe Hypertension: Begin with 50/12.5mg once daily, which may be increased to 100/25mg if required.
• Left Ventricular Hypertrophy: Initial dose is 50/12.5mg, which can be escalated to 100/12.5mg or 100/25mg based on blood pressure response.

Side Effects

Some mild side effects include dizziness, hyperkalemia, headache, and gastrointestinal discomfort. Rarely, serious side effects such as renal impairment, angioedema, and hypotension may occur.

How to Use

Take the medication once daily with or without food. It is recommended to take it at the same time each day for best results. Follow your doctor’s instructions for dosage adjustments.

Pregnancy & Lactation

Avoid use during pregnancy as it may affect fetal blood pressure and kidney function. It is also not recommended during breastfeeding due to insufficient safety data.

Precautions and Warnings

• Monitor serum electrolyte levels regularly
• Caution in patients with renal impairment or a history of angioedema
• Potassium supplements should be avoided unless prescribed

Safety Information

• Avoid potassium-sparing diuretics and NSAIDs, as they may reduce the drug's effectiveness
• Alcohol may cause orthostatic hypotension

Indications

Primarily indicated for hypertension and stroke risk reduction in individuals with left ventricular hypertrophy.

Pharmacology

Losartan blocks the action of angiotensin II, preventing vasoconstriction. Hydrochlorothiazide promotes fluid excretion by affecting renal tubular function. Together, they lower blood pressure by different mechanisms, providing a comprehensive solution for hypertension.

Therapeutic Class

Combined antihypertensive preparations

Storage Conditions

Store below 30°C. Keep out of reach of children.

FAQs

1. Can Losan Plus cause dizziness?
   Yes, some patients may experience dizziness, especially when starting the treatment.
2. Is it safe to take during pregnancy?
   No, it should be avoided unless necessary.
3. How long does it take to see the effects?
   A full antihypertensive effect is usually achieved within three weeks.

Disclaimer

Always consult your doctor before starting, stopping, or adjusting your medication. This information is not a substitute for professional medical advice.

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