Generic
Linagliptin 2.5 mg + Metformin Hydrochloride 850 mg

Description
Lino-M 850 is a combination antidiabetic medication that helps control high blood sugar in adults with type 2 diabetes mellitus. It effectively combines two drugs: Ligandliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and Metformin, a biguanide. Together, they provide synergistic action to manage blood glucose levels in patients inadequately controlled with diet, exercise, or other antidiabetic medicines.

Benefits
Lino-M 850 improves glycemic control by targeting both fasting and post-meal glucose levels. It reduces glucose production in the liver, enhances insulin sensitivity, and stimulates insulin secretion from the pancreas, providing comprehensive management for type 2 diabetes.

Ingredients
Each Lino-M 850 tablet contains:

• Linagliptin 2.5 mg
• Metformin Hydrochloride 850 mg

Uses and Doses
Lino-M 850 is indicated for managing type 2 diabetes mellitus as an adjunct to diet and exercise.

• For patients new to Metformin: Start with 2.5 mg Linagliptin/500 mg Metformin Hydrochloride twice daily.
• For those already on Metformin, Adjust the dose to 2.5 mg of Linagliptin and the current dose of metformin twice daily.
• Maximum dose: 2.5 mg Linagliptin/1000 mg Metformin Hydrochloride twice daily.
  It should always be taken with meals to reduce gastrointestinal side effects.

Side Effects
Common side effects include diarrhea, nausea, vomiting, upset stomach, nasal congestion, sore throat, respiratory infections, and hypoglycemia (when taken with sulfonylureas or insulin). Rare adverse events such as pancreatitis and vitamin B12 deficiency have been reported.

How to Use
Take Lino-M 850 precisely as directed by your physician. Swallow the tablets whole with a meal to minimize gastrointestinal discomfort. For optimal results, monitor your blood sugar levels regularly.

Pregnancy & Lactation
Lino-M 850 is not recommended during pregnancy due to insufficient evidence of safety. It should be used during lactation only if needed and after consulting a doctor, as Metformin is excreted in breast milk, and Linagliptin's effects are unknown.

Precautions and Warnings
Monitor for lactic acidosis, especially in renal impairment or alcohol abuse. Discontinue temporarily in iodinated contrast imaging or surgical procedures requiring restricted food and liquid intake. Regular monitoring of renal and liver function is necessary. Inform your doctor immediately if symptoms of pancreatitis or severe hypoglycemia occur.

Safety Information
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children. Do not use expired medication.

Indications
Lino-M 850 is indicated for type 2 diabetes mellitus when diet, exercise, and individual drugs such as Linagliptin or Metformin alone are insufficient to control blood glucose.

Pharmacology
Linagliptin inhibits DPP-4, enhancing incretin hormones, which boost insulin release and reduce glucagon secretion. Metformin lowers hepatic glucose production, improves insulin sensitivity, and increases glucose uptake in muscles, achieving effective blood sugar management.

Therapeutic Class
Combination of Oral Hypoglycemic Agents

Storage Conditions
Store below 30°C in a cool, dry place, shielded from moisture and light. Keep this medication out of children’s reach.

3 FAQ

1. What is Lino-M 850 used for?
   It manages blood sugar in adults with type 2 diabetes mellitus.
2. Can I stop taking Lino-M 850 if my blood sugar is controlled?
   No, continue treatment unless advised by your doctor to prevent complications.
3. What should I do if I miss a dose?
   Take the missed dose as soon as possible, or skip it if it is close to the next scheduled dose. Do not double doses.

Disclaimer
This information is intended for educational purposes and should not replace medical advice from your healthcare provider.

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