Generic

Linezolid 400mg

Description

Linezolid is a synthetic antibacterial drug from the oxazolidinone class, effective against Gram-positive aerobic and anaerobic bacteria. It works uniquely by inhibiting bacterial protein synthesis.

Benefits

• Effective against Vancomycin-Resistant Enterococcus faecium and multi-drug-resistant strains of bacteria.
• Treats complicated skin infections, nosocomial, and community-acquired pneumonia.
• Offers bacteriostatic and bactericidal properties for specific bacterial strains.

Ingredients

Active Ingredient: Linezolid 400mg.
Inactive Components: Stabilizers and excipients for oral or intravenous formulations.

Uses and Doses

For adults and adolescents, Linezolid 400mg is administered orally twice daily for uncomplicated skin infections or pneumonia. Pediatric dosages vary based on age and condition, typically calculated per kg of body weight.

Side Effects

Common side effects include diarrhea, headache, nausea, hypertension, and oral or vaginal moniliasis. Rare effects may involve seizures, tongue discoloration, and serotonin syndrome.

How to Use

For oral suspension, mix with 75 ml cooled boiled water in two portions, shaking well each time. For IV injection, administer over 30-120 minutes. Oral tablets can be taken with or without food.

Pregnancy & Lactation

Classified under Pregnancy Category C, Linezolid should be used during pregnancy only if benefits outweigh risks. Caution is advised for breastfeeding mothers as excretion in milk is unknown.

Precautions and Warnings

Monitor patients for symptoms like unexplained nausea, visual impairment, or serotonin syndrome. Those with seizure history should use Linezolid cautiously. Avoid usage with recent monoamine oxidase inhibitors or uncontrolled hypertension.

Safety Information

Keep Linezolid formulations out of reach of children. Maintain proper storage conditions to ensure drug efficacy.

Indications

Linezolid treats infections caused by Vancomycin-resistant Enterococcus faecium, complicated skin infections, and both community-acquired and nosocomial pneumonia.

Pharmacology

Linezolid binds to the bacterial ribosome, preventing protein synthesis. It demonstrates bacteriostatic action against enterococci and staphylococci and bactericidal activity against streptococci.

Therapeutic Class

Macrolides

Storage Conditions

Store at 15°C-30°C away from light and moisture. Avoid freezing the IV formulation.

FAQs

1. What is Linezolid used for?
   Linezolid is used to treat bacterial infections, including resistant strains of Gram-positive bacteria.
2. Can Linezolid be used during pregnancy?
   It should be used only if the potential benefits outweigh the risks. Consult your doctor.
3. What should I avoid while using Linezolid?
   Avoid using serotonin reuptake inhibitors or adrenergic drugs without medical supervision.

Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Consult your doctor for personalized guidance on using Linez.

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