Generic
Sitagliptin + Metformin Hydrochloride

Description
Janmet 1000 is a combination medication developed to aid in glycemic control for adults with type 2 diabetes mellitus, primarily intended to be used with a healthy diet and exercise. It contains two active ingredients: Sitagliptin and Metformin Hydrochloride, which together regulate blood sugar levels, reducing risks associated with high blood glucose, such as kidney damage, heart complications, and blindness.

Benefits
The Janmet 1000 tablet combines Sitagliptin and Metformin, working synergistically to improve blood glucose levels, reducing postprandial and basal glucose levels effectively. By combining two mechanisms, it supports sustained glycemic control while minimizing risks like hypoglycemia compared to other therapies.

Ingredients
Each Janmet 1000 tablet contains:

• Sitagliptin Phosphate Monohydrate INN 50 mg
• Metformin Hydrochloride BP 1000 mg

Uses and Doses
Primarily indicated for the management of type 2 diabetes mellitus, Janmet 1000 is to be taken with meals to reduce potential gastrointestinal discomfort. The dosage depends on the patient's current medical regimen, effectiveness, and tolerance, with a maximum allowable daily dose of Sitagliptin 100 mg and Metformin 2000 mg. It’s essential to follow the healthcare provider’s prescribed dosage.

Side Effects
Common side effects include:

• Gastrointestinal issues such as nausea, vomiting, and diarrhea
• Headaches and respiratory tract infections
• Low blood sugar, especially if used in combination with insulin or sulfonylurea Rare side effects may include lactic acidosis, hypersensitivity reactions, and pancreatitis.

How to Use
Take Janmet 1000 with meals, preferably in divided doses as per your doctor's guidance. Swallow whole without crushing or breaking to maintain its efficacy. For best results, maintain regular dosing schedules, typically twice daily.

Pregnancy & Lactation
Janmet 1000 is classified under Pregnancy Category B, meaning there’s no conclusive research in humans. Pregnant or breastfeeding women should consult their healthcare provider before using this medication to ensure it’s safe.

Precautions and Warnings
Patients with renal impairment, metabolic acidosis, or pancreatitis history should avoid Janmet 1000. Regular blood work and renal function tests are recommended for those with potential risk factors. Excessive alcohol consumption can increase lactic acidosis risk, so intake should be minimized.

Safety Information
Not suitable for type 1 diabetes or diabetic ketoacidosis treatment. Janmet 1000 may cause hypoglycemia when combined with other diabetes medications; dosage adjustments are advised.

Indications
Indicated for adults with type 2 diabetes mellitus requiring additional glycemic control support in combination with diet and exercise.

Pharmacology
Janmet 1000 uses Sitagliptin to inhibit the DPP-4 enzyme, increasing incretin hormones, and Metformin to reduce hepatic glucose production, decrease glucose absorption, and increase insulin sensitivity, achieving an effective glycemic balance.

Therapeutic Class
Oral hypoglycemic agents in combination.

Storage Conditions
Store below 25°C in a dry place away from light, and keep out of children’s reach. Do not use beyond the expiry date.

3 FAQ

1. Can Janmet 1000 be used alone for type 2 diabetes?
   Janmet 1000 is effective both alone and in combination with other diabetes medications for improved blood sugar control.
2. What should I do if I miss a dose?
   If you miss a dose, take it as soon as possible with a meal. Skip it if your next dose is almost due to avoid double dosing.
3. What precautions are necessary with Janmet 1000?
   Avoid excessive alcohol and ensure regular monitoring of blood glucose and kidney function, especially if you have existing kidney issues.

Disclaimer
This information does not replace medical advice. Please consult your healthcare provider to ensure this medication is right for you.

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