Generic
Clobetasol Propionate + Neomycin Sulfate + Nystatin

Description
Exovate N 25 is a combination topical cream used to treat severe inflammatory skin disorders, psoriasis, and eczema with bacterial or fungal infections. It contains Clobetasol Propionate (a potent corticosteroid), Neomycin Sulfate (an antibiotic), and Nystatin (an antifungal), making it practical for resistant skin conditions with secondary infections.

Benefits
Exovate N 25 provides anti-inflammatory, antibacterial, and antifungal action, effectively treating eczema, psoriasis, and severe inflammatory skin conditions. It helps reduce swelling, redness, itching, and skin infections, promoting faster healing.

Ingredients
Each gram of Exovate N 25 contains:

• Clobetasol Propionate 0.5mg – a potent corticosteroid that reduces inflammation.
• Neomycin Sulfate 5mg – an aminoglycoside antibiotic that fights bacterial infections.
• Nystatin 100,000 IU – an antifungal agent that prevents and treats fungal infections.

Uses and Doses
Exovate N 25 is used for psoriasis, eczema, and severe inflammatory skin disorders with bacterial or fungal infections.

• Adults: Apply a thin layer once or twice daily until improvement occurs. Do not use for more than 7 days without medical supervision.
• Children (2+ years): Apply as in adults but avoid prolonged use due to increased absorption risk.
• Elderly: Use caution if kidney function is impaired due to potential systemic absorption of Neomycin.

Side Effects
Common side effects include skin thinning, burning sensation, irritation, redness, itching, and rash. Prolonged use may cause Cushing’s syndrome, diabetes, hypertension, or adrenal suppression.

How to Use
Apply a thin layer to the affected area once or twice daily. Do not cover with a dressing unless advised. Avoid contact with the eyes, nose, and mouth. Wash hands after application.

Pregnancy & Lactation
The safety of Exovate N 25 during pregnancy and breastfeeding is not well established. Avoid use unless prescribed by a doctor. Neomycin can cross the placenta, posing a potential risk to the fetus.

Precautions and Warnings
Long-term use should be avoided, especially in infants and children, as it may cause adrenal suppression. Do not use near the eyes to prevent glaucoma or cataracts. Avoid use on the face for more than 5 days.

Safety Information
Systemic absorption of Neomycin may cause respiratory depression if combined with neuromuscular blockers. Exovate N 25 should not be used in rosacea, acne, perioral dermatitis, viral skin infections (e.g., herpes, chickenpox), or open wounds.

Indications
Exovate N 25 is indicated for psoriasis, eczema, and severe inflammatory skin disorders, mainly when secondary bacterial or fungal infections are present or likely to occur.

Pharmacology
Clobetasol Propionate acts as a potent corticosteroid, reducing inflammation. Neomycin inhibits bacterial protein synthesis, preventing bacterial infections. Nystatin disrupts fungal cell membranes, stopping fungal growth.

Therapeutic Class
Clobetasol, Clobetasone, and Combination Preparations.

Storage Conditions
Store below 25°C, away from light and moisture. Keep out of reach of children.

Frequently Asked Questions (FAQ)

1. Can Exovate N 25 be used for fungal infections?
Yes, it contains Nystatin, which is effective against fungal infections. However, prolonged use should be monitored by a doctor.

2. How long can I use Exovate N 25?
Use for a maximum of 7 days unless prescribed otherwise. Prolonged use may lead to skin thinning and systemic side effects.

3. Can Exovate N 25 be used on the face?
It can be used on the face only under medical supervision and for no more than 5 days to prevent skin thinning and damage.

Disclaimer

This content is for informational purposes only and does not replace medical advice. Always consult a doctor before using any medication.

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