Generic
Esomeprazole Magnesium Trihydrate

Description
Esoral 40 is a tablet containing 40mg of Esomeprazole Magnesium, a proton pump inhibitor designed to treat various acid-related conditions such as GERD, gastric ulcers, and Zollinger-Ellison syndrome. It helps by reducing acid production in the stomach, providing relief from symptoms like heartburn and preventing complications like erosive esophagitis.

Benefits

• Relieves chronic heartburn and GERD symptoms
• Aids in healing erosive esophagitis
• Combats Helicobacter pylori when combined with antibiotics
• Treats Zollinger-Ellison Syndrome and other acid-related conditions

Ingredients
Esomeprazole Magnesium Trihydrate 40mg

Uses and Doses

• Healing Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks
• GERD: 20 mg once daily for 4 weeks
• Helicobacter Pylori Eradication: 40 mg daily for 10 days alongside antibiotics
• Zollinger-Ellison Syndrome: 20-80 mg once daily, depending on the patient
• Duodenal & Gastric Ulcer: 20-40 mg once daily

Side Effects
Common side effects include headache, diarrhea, nausea, flatulence, abdominal pain, and constipation. Rarely, patients may experience skin reactions like dermatitis, dizziness, or dry mouth.

How to Use
Take Esoral 40 tablets one hour before a meal. Swallow the tablet whole without crushing or chewing. For oral suspension, mix with water, stir, and consume within 30 minutes. For IV injection, the recommended dose is 40 mg, administered slowly over 3 minutes.

Pregnancy & Lactation
Esoral 40 is classified as pregnancy category B, indicating it is safe for use during pregnancy. However, it is advised to consult a healthcare provider before use during breastfeeding due to unknown effects on nursing infants.

Precautions and Warnings
Do not use if allergic to Esomeprazole or benzimidazole derivatives. Ensure no signs of gastric cancer before starting treatment. Always follow the prescribed dosage and consult a doctor for long-term use.

Safety Information
Avoid using Esoral 40 with medications that depend on stomach acid for absorption. There are no significant interactions with drugs like warfarin or clarithromycin, but diazepam levels may rise with concurrent use.

Indications
Used for GERD, healing erosive esophagitis, preventing duodenal ulcers, and treating Zollinger-Ellison syndrome.

Pharmacology
Esomeprazole inhibits the H+/K+-ATPase enzyme in gastric parietal cells, reducing stomach acid production. The drug is metabolized in the liver, primarily through the CYP2C19 enzyme, with inactive metabolites excreted in urine and feces.

Therapeutic Class
Proton Pump Inhibitor (PPI)

Storage Conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.

FAQ

1. How long should I take Esoral 40? Follow your doctor’s instructions, typically 4-8 weeks for erosive esophagitis and up to 10 days for H. pylori eradication.
2. Can I take Esoral 40 during pregnancy? Yes, it is category B, but consult your doctor before use.
3. What happens if I miss a dose? Take it as soon as possible unless it’s near the time of the next dose. Don’t double up doses.

Disclaimer
This information is for educational purposes only. Consult your healthcare provider for medical advice, diagnosis, and treatment.

Keywords: Esomeprazole, GERD, gastric ulcer, proton pump inhibitor, Esoral, Zollinger-Ellison, acid reflux, heartburn relief, stomach acid, Helicobacter pylori, duodenal ulcer, gastroesophageal reflux, esophagitis, SK+F, acid-related dyspepsia, gastric protection, chronic heartburn, proton pump, gastric parietal cells, H+/K+-ATPase inhibitor.