Generic

Domin 10 contains Domperidone Maleate 10 mg, a dopamine antagonist that enhances gastrointestinal motility and helps relieve nausea, vomiting, and digestive discomfort.

Description

Domin 10 is a prokinetic drug that stimulates gastrointestinal motility and helps in conditions such as nausea, vomiting, bloating, and delayed stomach emptying. It is commonly prescribed for patients with dyspeptic symptoms, gastroesophageal reflux, and nausea caused by medications, infections, or dietary factors.

Benefits

Domin 10 improves gastric motility, reduces bloating, and enhances stomach emptying. It is particularly effective for treating nausea and vomiting caused by functional disorders, medication therapy, infections, or radiation. The medication also helps relieve dyspepsia, gastroesophageal reflux, and abdominal discomfort, making it beneficial for individuals with chronic digestive issues.

Ingredients

Each tablet contains 10 mg of domperidone maleate, which blocks dopamine receptors in the stomach, promotes normal gastric function, and prevents nausea and vomiting.

Uses and Doses

Domin 10 is taken 15-30 minutes before meals and, if needed, before bedtime. The usual recommended dose:

• Adults: 10-20 mg (1-2 tablets) every 6-8 hours, with a maximum daily dose of 80 mg.
• Children: 2-4 ml suspension per 10 kg body weight every 6-8 hours.
• Adults should take 20 mg (2 tablets) every 6-8 hours for acute nausea and vomiting, and children should take 0.2-0.4 mg/kg body weight every 6-8 hours.
• For rectal administration, Adults take 30-60 mg every 4-8 hours, and children receive a maximum daily dose of 30 mg.

Side Effects

Domin 10 may cause mild side effects, including dry mouth, thirst, headache, drowsiness, anxiety, diarrhea, and skin rash. In rare cases, it may lead to hyperprolactinemia, causing symptoms like breast enlargement, galactorrhea, or decreased libido. Extrapyramidal reactions are infrequent.

How to Use

Take Domin 10 before meals with a glass of water. Do not exceed the recommended dosage. If a dose is missed, take it as soon as possible, but do not double it.

Pregnancy & Lactation

The safety of Domin 10 during pregnancy has not been established. While animal studies have not observed teratogenicity, it is generally not recommended for pregnant women. Domperidone can enhance postpartum lactation and is excreted in small amounts in breast milk, but it is not considered harmful for breastfeeding infants.

Precautions and Warnings

Domin 10 should be used cautiously in children, as they have a higher risk of extrapyramidal effects. Patients with liver impairment should take the medication under medical supervision due to its metabolism in the liver. The drug is not recommended in cases of gastrointestinal bleeding, obstruction, or prolactin-releasing tumors.

Safety Information

Patients should not take Domin 10 with known hypersensitivity to Domperidone. Avoid taking it with opioid analgesics or MAO inhibitors, as they may affect its effectiveness. The medication should be stored safely away from children.

Indications

Domin 10 is used for dyspeptic symptoms, nausea, vomiting, bloating, and delayed stomach emptying. It is also effective in treating gastroesophageal reflux, preparation for radiological investigations, and nausea caused by Parkinson’s disease dopamine agonists.

Pharmacology

Domperidone acts as a dopamine antagonist, blocking dopamine receptors in the stomach and the chemoreceptor trigger zone (CTZ). This prevents nausea and vomiting while improving gastric emptying and peristalsis. Unlike other dopamine antagonists, Domperidone does not cross the blood-brain barrier, reducing the risk of neurological side effects.

Therapeutic Class

Motility Stimulants / Prokinetic Drugs

Storage Conditions

Store Domin 10 below 30°C, away from light and moisture. Keep it out of the reach of children.

FAQ

1. Can I take Domin 10 on an empty stomach?
Yes, taking Domin 10 15-30 minutes before meals is recommended for better effectiveness.

2. How long does it take for Domin 10 to work?
The effects usually appear in 30 to 60 minutes, and complete relief occurs within 1 to 2 hours.

3. Can Domin 10 be taken with other medications?
Domin 10 should not be taken with opioid painkillers or MAO inhibitors, as they can reduce its effectiveness or cause interactions.

Disclaimer

This information is for educational purposes only. Always consult a healthcare professional before using Domin 10, especially if you have existing medical conditions or are pregnant or breastfeeding.

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