Diflu 150 Capsule Guide

Generic
Fluconazole

Description
Diflu 150, manufactured by Aristopharma Ltd., contains Fluconazole 150 mg, an antifungal medication in capsule form. It is commonly used to treat various types of candidiasis, including vaginal, oropharyngeal, esophageal, and systemic infections caused by Candida species, along with other fungal infections.

Benefits
Diflu 150 effectively treats fungal infections by targeting the fungal cell membrane and inhibiting ergosterol synthesis, which is essential for fungal growth. The capsule is easy to administer, requiring only a single dose in certain conditions.

Ingredients
The active ingredient is Fluconazole 150 mg. Inactive components may include various excipients for stability and absorption.

Uses and Doses
Adults with vaginal candidiasis take a single dose of 150 mg orally. For oropharyngeal and esophageal candidiasis, 200 mg is taken on the first day, followed by 100 mg once daily for at least two weeks. Systemic and urinary tract infections may require 50-200 mg daily, while cryptococcal meningitis initially requires 400 mg on the first day, followed by 200 mg daily. Children may be dosed based on weight, typically 3-6 mg/kg daily.

Side Effects
The most common side effects are nausea, vomiting, abdominal pain, diarrhea, headache, and rash. Rarely, it may cause liver toxicity, QT prolongation, or allergic reactions such as Stevens-Johnson syndrome.

How to Use
Diflu 150 can be taken with or without food, though oral suspension forms require reconstitution. Tablets should be swallowed whole without breaking or chewing.

Pregnancy & Lactation
Category C: Fluconazole is not recommended during pregnancy unless necessary due to potential risks to the fetus. Women should consult their doctor about alternative antifungals during pregnancy and lactation.

Precautions and Warnings
Caution is advised in patients with liver or kidney impairment, as well as those at risk for arrhythmias due to possible QT prolongation. Avoid using with other medications that may prolong the QT interval.

Safety Information
Use with caution in conjunction with cyclosporin, phenytoin, warfarin, rifampicin, and certain other drugs. Avoid combining with alcohol and other central nervous system depressants.

Indications
Indicated for treating vaginal, oropharyngeal, esophageal, and systemic candidiasis, along with cryptococcal meningitis and prophylaxis in bone marrow transplant patients.

Pharmacology
Fluconazole is a triazole antifungal that inhibits fungal cytochrome P-450, interfering with ergosterol production, essential for fungal cell membrane integrity.

Therapeutic Class
Antifungal agent for subcutaneous and systemic fungal infections.

Storage Conditions
Store in a dry place, away from direct light and heat, at a temperature below 30°C. Keep out of reach of children.

3 FAQ

1. Can Diflu 150 treat fungal infections other than Candida?
   Primarily indicated for Candida infections, Diflu 150 is also used for specific cases of cryptococcal meningitis.
2. Is Diflu 150 safe during breastfeeding?
   Caution is advised as Fluconazole passes into breast milk. Consult a physician before use.
3. Can Diflu 150 cause drowsiness?
   Fluconazole generally does not cause drowsiness; however, if unusual symptoms occur, contact your healthcare provider.

Disclaimer
Information provided here is not a substitute for medical advice. Consult a healthcare professional for any questions or concerns regarding Diflu 150 usage.

Keywords: Fluconazole, Diflu 150, antifungal, Candida infection, cryptococcal meningitis, Aristopharma, oral capsule, fungal treatment, candidiasis, esophageal candidiasis, vaginal candidiasis, systemic infection, yeast infection, Diflu, antifungal capsule, drug interactions, side effects, QT prolongation, liver toxicity, medication guide