Generic
Domperidone Maleate 5mg

Description
Deflux 15 ml Pediatric Drops is a medication primarily used to relieve dyspeptic symptoms associated with delayed gastric emptying, gastroesophageal reflux, and esophagitis. It is manufactured by Beximco Pharmaceuticals Ltd., and contains Domperidone Maleate, which improves gastrointestinal motility by blocking dopamine receptors in the stomach, facilitating smoother gastric emptying and reducing symptoms like nausea, vomiting, and bloating.

Benefits

• Relieves nausea and vomiting caused by various conditions
• Eases discomfort related to bloating, fullness, and indigestion
• Improves gastric motility and prevents reflux
• Safe for use in both adults and children under specific dosing guidelines

Ingredients
Active Ingredient: Domperidone Maleate 5mg
Inactive Ingredients: Stabilizers, preservatives, and suspension base.

Uses and Doses
Domperidone should be taken 15-30 minutes before meals.
Adults: 10-20 mg every 6-8 hours (maximum 80 mg/day)
Children: 0.2-0.8 ml per 10 kg body weight every 6-8 hours
In cases of acute nausea and vomiting, higher doses may be recommended.
The treatment duration should not exceed 12 weeks.

Side Effects
Potential side effects of Deflux include hyperprolactinemia (1.3%), dry mouth (1%), headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), rash (0.1%), and in rare cases, extrapyramidal reactions (0.05%).

How to Use
For best results, take Deflux between 15 to 30 minutes before meals or at bedtime. Measure the pediatric drops carefully, following the prescribed dose for your weight or the child’s weight.

Pregnancy & Lactation
Deflux's safety during pregnancy has not been established. It is not recommended for use during pregnancy. Small amounts of domperidone are secreted in breast milk but are not considered harmful to infants. The drug may stimulate lactation postpartum.

Precautions and Warnings
Avoid use in patients with gastrointestinal bleeding, obstruction, or perforation. Patients with prolactin-releasing pituitary tumors should not take Deflux. Care should be taken when combining this drug with monoamine oxidase inhibitors (MAOIs) or opioid analgesics.

Safety Information
Deflux should not be used in newborns or individuals allergic to domperidone. Avoid in situations where gastrointestinal irritation is present.

Indications
Deflux 15 ml is indicated for dyspeptic symptoms related to delayed gastric emptying, gastroesophageal reflux, nausea, vomiting, and functional or infectious gastrointestinal conditions. It can also be used for nausea and vomiting caused by Parkinson’s disease treatments.

Pharmacology
Domperidone acts as a dopamine antagonist, blocking dopamine receptors in the stomach and CTZ. This improves gastrointestinal motility by enhancing peristalsis, promoting gastric emptying, and reducing esophageal reflux, with minimal central nervous system side effects due to limited blood-brain barrier permeability.

Therapeutic Class
Sports stimulants, dopamine antagonists, prokinetics

Storage Conditions
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.

3 FAQ

1. Can Deflux be used during pregnancy?
   It is not recommended due to insufficient safety data.
2. What is the maximum daily dosage for children?
   For children, the dosage is based on body weight, generally 0.2-0.8 ml/10 kg every 6-8 hours.
3. How long can I take Deflux?
   Treatment duration should not exceed 12 weeks.

Disclaimer
Consult your healthcare provider before starting or stopping Deflux. The information provided is not a substitute for professional medical advice.

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