Generic: Metformin Hydrochloride

Description: Comet 850, manufactured by Square Pharmaceuticals, contains 850 mg of Metformin Hydrochloride. It is an antihyperglycemic agent used to manage type 2 diabetes by improving glycemic control in both children and adults.

Benefits:

• Improves glucose tolerance in type 2 diabetes
• Lowers both basal and postprandial plasma glucose
• Does not cause hypoglycemia or hyperinsulinemia
• Enhances insulin sensitivity and reduces glucose absorption

Ingredients: Metformin Hydrochloride 850 mg

Uses and Doses: Comet 850 is used as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. Adults can start with 850 mg once daily, with gradual dose increases to a maximum of 2000 mg per day. Pediatric patients can use up to 2000 mg per day in divided doses.

Side Effects: Common side effects include gastrointestinal discomfort such as nausea, vomiting, and diarrhea. Rare side effects include lactic acidosis, liver function abnormalities, and skin reactions. Prolonged use may reduce vitamin B12 absorption.

How to Use: Take Comet 850 with meals to reduce gastrointestinal side effects. Do not crush or chew the tablet. The dosage should be adjusted based on the effectiveness and tolerance of the medication.

Pregnancy & Lactation: Comet 850 falls under Pregnancy Category B. Insulin is recommended for managing blood sugar during pregnancy. Metformin should only be used if absolutely necessary during pregnancy.

Precautions and Warnings: Patients with renal dysfunction or creatinine levels above the recommended limit should not use Comet 850 due to the increased risk of lactic acidosis. Elderly patients must be carefully titrated.

Safety Information: Store Comet 850 in a cool, dry place away from light and moisture. Keep out of reach of children.

Indications: Comet 850 is indicated for the treatment of type 2 diabetes in both children and adults, alongside diet and exercise.

Pharmacology: Metformin reduces hepatic glucose production and enhances insulin sensitivity, improving glucose uptake and utilization. It does not cause hypoglycemia and does not result in hyperinsulinemia.

Therapeutic Class: Biguanides

Storage Conditions: Store in a cool, dry place away from direct sunlight. Keep out of reach of children.

3 FAQ:

1. Can Comet 850 cause hypoglycemia?
   No, Comet 850 does not induce hypoglycemia in patients with type 2 diabetes or normal individuals.
2. Can I take Comet 850 during pregnancy?
   It is advised to use insulin during pregnancy. Metformin should only be taken if necessary.
3. How long does it take for Comet 850 to work?
   The onset of action may vary, but it generally starts improving glycemic control within a few days of use.

Disclaimer: This information is for educational purposes only. Always consult your healthcare provider before making any medical decisions.

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