Generic
Metformin Hydrochloride 500mg

Description
Comet 500 is an antidiabetic medication used to manage type 2 diabetes, particularly in overweight individuals when diet and exercise alone are insufficient to control blood sugar levels. Manufactured by Square Pharmaceuticals Limited, it is a safe and effective first-line treatment for diabetes management.

Benefits
Comet 500 helps lower blood sugar levels, reduces diabetic complications, improves insulin sensitivity, and aids in weight management in diabetic patients. It can be taken alone or in combination with other oral antidiabetic drugs or insulin.

Ingredients
Each tablet contains 500mg of Metformin Hydrochloride as the active ingredient.

Uses and Doses
For adults, Comet 500 is typically started at 500 mg twice a day or 850 mg once daily, with meals. The dose may be increased weekly in 500 mg increments up to a maximum of 2000 mg daily. In children aged 10 and older, the starting dose is 500 mg twice daily, with adjustments up to 2000 mg per day based on efficacy.

Side Effects
Common side effects include gastrointestinal issues such as nausea, vomiting, diarrhea, and loss of appetite. Rare side effects may include lactic acidosis, vitamin B12 deficiency, and skin reactions. In case of persistent or severe side effects, consult a healthcare professional.

How to Use
Take Comet 500 with meals to reduce gastrointestinal discomfort. Swallow the tablet whole with water. Do not crush or chew the tablet. Always follow the recommended dose prescribed by your healthcare provider.

Pregnancy & Lactation
While metformin is secreted in breast milk, no harmful effects have been reported in breastfed infants. However, it is generally recommended to manage diabetes with insulin during pregnancy to minimize risks. Consult with your doctor before using Comet 500 during pregnancy or breastfeeding.

Precautions and Warnings
Comet 500 is contraindicated in patients with severe renal impairment and those at risk of lactic acidosis. Regular monitoring of kidney function is advised, and the medication should be discontinued if renal function deteriorates. Long-term use may lead to vitamin B12 deficiency.

Safety Information
Do not use Comet 500 if you have hypersensitivity to metformin or its excipients, metabolic acidosis, severe renal failure, or any condition that may alter renal function. Avoid alcohol consumption while taking Comet 500.

Indications
Comet 500 is indicated for the treatment of type 2 diabetes mellitus, particularly in overweight individuals, when lifestyle changes are inadequate. It can be used alone or with other oral antidiabetic agents or insulin.

Pharmacology
Metformin belongs to the biguanide class of drugs, working by reducing hepatic glucose production, lowering intestinal glucose absorption, and improving peripheral glucose uptake and utilization. It helps control both fasting and postprandial glucose levels without causing hypoglycemia.

Therapeutic Class
Biguanides

Storage Conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.

3 FAQ

1. Can Comet 500 be used for weight loss?
   No, Comet 500 is not specifically indicated for weight loss but may assist in weight management in diabetic patients.
2. Is Comet 500 safe for children?
   Yes, Comet 500 can be used in children aged 10 and above under medical supervision.
3. How long does it take for Comet 500 to work?
   It may take a few days to weeks for Comet 500 to show its full effect in lowering blood sugar levels.

Disclaimer
This information is not intended to replace professional medical advice. Always consult with your healthcare provider before starting or discontinuing any medication.

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