Generic: Silver Sulfadiazine 1%

Description: Burna 25 is a topical antibacterial cream produced by Square Pharmaceuticals Limited. It contains 1% Silver Sulfadiazine, used primarily for the prevention and treatment of bacterial infections in burn wounds. Its formulation helps fight infection while promoting healing in affected skin areas.

Benefits:

• Prevents bacterial infection in burn wounds
• Provides antibacterial protection for contaminated or infection-prone wounds
• Helps in the healing process
• Reduces the risk of complications due to infections

Ingredients: The active ingredient is Silver Sulfadiazine 1%. Additional inactive ingredients are present to support the cream's stability and application.

Uses and Doses: Burna 25 is applied topically over burn wounds to prevent bacterial colonization and infection. The recommended dosage is to apply a 1/16 inch thick layer (1.5 mm) once or twice daily. The area should remain covered with the cream at all times, and it should be reapplied after any removal due to patient activity. The treatment continues until healing or skin grafting is ready.

Side Effects: Common side effects include transient leukopenia, skin necrosis, erythema multiform, skin discoloration, rashes, and burning sensations. In rare cases, interstitial nephritis may occur.

How to Use: Cleanse the burn wound and apply a thin layer of the cream. Reapply as necessary, especially after hydrotherapy or removal. Dressings may be used if needed. The cream should be used until the burn wound heals satisfactorily.

Pregnancy & Lactation: Burna 25 is classified as Pregnancy Category B. It should only be used during pregnancy if essential, particularly for women at or near term. Its safety during lactation is not well-established, and a healthcare provider should decide whether to continue or stop breastfeeding or the drug.

Precautions and Warnings: Patients with renal or hepatic impairment should use this cream cautiously due to the potential for drug accumulation. Silver sulfadiazine may inactivate certain proteolytic enzymes used for wound care. Monitoring of renal function and serum sulfa levels is advised for patients with extensive burns.

Safety Information: Do not use Burna 25 if you are allergic to Silver Sulfadiazine or any other ingredients. It should not be used on premature infants, newborns, or pregnant women close to term. Consult with a healthcare provider if you have any preexisting conditions or if taking other medications.

Indications: Burna 25 is indicated for the prevention and treatment of bacterial colonization and infection in burn wounds and other infection-prone wounds.

Pharmacology: Silver Sulfadiazine works by causing structural changes to bacterial cells and preventing their replication by binding to bacterial DNA. The silver component exerts its effects more on bacterial cells than on mammalian cells, aiding the healing process without significantly harming epithelial cells.

Therapeutic Class: Topical Antibiotic preparations.

Storage Conditions: Store Burna 25 below 30°C, away from light and moisture, and out of reach of children.

FAQ:

1. Can I use Burna 25 on minor cuts or scrapes?
   It is primarily for burn wounds, but consult your doctor for advice on using it for other wound types.
2. How often should I apply Burna 25?
   Apply once or twice daily, ensuring the area is always covered with the cream.
3. Is Burna 25 safe for children?
   Its safety in pediatric patients has not been fully established, so consult a healthcare professional.

Disclaimer: This information is intended for educational purposes and should not replace professional medical advice. Always consult with a healthcare provider for diagnosis and treatment options.

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