Generic

Angilock Plus 50/12.5 is a combination medication containing two active ingredients: Losartan Potassium 50mg and Hydrochlorothiazide 12.5mg. It is designed to treat hypertension and is available under Square Pharmaceuticals Limited.

Description

Angilock Plus 50/12.5 is a prescription medication used to control high blood pressure. It combines two active ingredients, Losartan and Hydrochlorothiazide, to effectively manage blood pressure levels and reduce the risk of related health complications.

Benefits

The medication helps in lowering high blood pressure, preventing stroke, and reducing the risk of cardiovascular events in patients with hypertension and left ventricular hypertrophy. It is a dual-action antihypertensive drug that enhances blood pressure control while offering a diuretic effect.

Ingredients

Each tablet of Angilock Plus 50/12.5 contains:

• Losartan Potassium 50mg
• Hydrochlorothiazide 12.5mg

Uses and Doses

For general hypertension, the starting dose is one tablet of Angilock Plus 50/12.5 once daily. The dosage may be increased to 100/25 for better blood pressure control. For patients with left ventricular hypertrophy or severe hypertension, dosages may vary according to blood pressure response and the doctor's recommendation. The maximum dose should not exceed 100/25 once daily.

Side Effects

Common side effects of Angilock Plus 50/12.5 include dizziness, headache, and gastrointestinal discomfort. Serious side effects may include hypotension, hyperkalemia, angioedema, or liver dysfunction. Rare effects include muscle pain, photosensitivity, and kidney failure.

How to Use

Take Angilock Plus 50/12.5 as prescribed by your doctor, usually once daily. The tablet should be swallowed with water. Do not crush or chew the tablet. Follow your doctor's advice for adjusting the dose based on your response to treatment.

Pregnancy & Lactation

Angilock Plus 50/12.5 should be avoided during pregnancy unless necessary due to potential harm to the fetus, such as skull defects. It is also not recommended during breastfeeding, as limited safety data is available. Alternative medications with safer profiles during pregnancy and lactation are suggested.

Precautions and Warnings

Patients with a history of hypersensitivity reactions, kidney or liver problems, or electrolyte imbalances should use this medication cautiously. Regular monitoring of kidney function and electrolytes is recommended during treatment.

Safety Information

Ensure that regular blood pressure checks and kidney function tests are performed. Watch for signs of dehydration, severe hypotension, or electrolyte imbalances. Discontinue the medication if severe reactions like angioedema occur.

Indications

Angilock Plus 50/12.5 is indicated for treating high blood pressure (hypertension), reducing the risk of stroke, and managing patients with left ventricular hypertrophy to improve cardiovascular health.

Pharmacology

Losartan Potassium blocks the AT1 receptors of angiotensin II, reducing vasoconstriction and aldosterone secretion. Hydrochlorothiazide, a thiazide diuretic, helps reduce plasma volume by increasing sodium and chloride excretion, leading to reduced blood pressure.

Therapeutic Class

Angilock Plus 50/12.5 belongs to the class of combined antihypertensive preparations. It combines an angiotensin II receptor antagonist with a diuretic to effectively manage hypertension.

Storage Conditions

Store Angilock Plus 50/12.5 below 30°C, away from moisture and heat. Keep the medication out of reach of children.

3 FAQ

1. What should I do if I miss a dose?
   If you miss a dose, take it as soon as you remember unless it's almost time for the next dose. Do not double the dose to make up for a missed one.
2. Can I take Angilock Plus 50/12.5 with other medications?
   Consult your doctor before combining Angilock Plus with other medications, especially potassium supplements, diuretics, or NSAIDs, as interactions may occur.
3. Is Angilock Plus safe for elderly patients?
   Angilock Plus is generally safe for elderly patients, but dose adjustments may be necessary. The maximum dose should not exceed 100/25 once daily in elderly individuals.

Disclaimer

This information is intended for general understanding and should not replace professional medical advice. Always consult a healthcare provider before starting or changing your treatment plan.