Generic:
Prazosin Hydrochloride

Description:
Alphapress XR 5 Tablet contains Prazosin Hydrochloride 5mg, a selective alpha-1 adrenergic receptor antagonist primarily used to treat hypertension, Raynaud's disease, congestive heart failure, and benign prostatic hyperplasia. It helps lower blood pressure by relaxing the blood vessels, improving blood flow, and reducing the strain on the heart. Manufactured by Renata Pharma Ltd.

Benefits:

• Effectively reduces high blood pressure.
• Relieves symptoms of benign prostatic hyperplasia (BPH).
• Reduces cardiac load in heart failure patients.
• Improves circulation in patients with Raynaud's disease.

Ingredients:
Prazosin Hydrochloride 5mg

Uses and Doses:

• Hypertension: Start with 0.5 mg twice/thrice daily for 3-7 days, increasing gradually. Usual maintenance dose: up to 15 mg/day in divided doses.
• Congestive Heart Failure: Start with 0.5 mg two to four times daily, gradually increasing to a maintenance dose of 4-20 mg/day.
• Raynaud's Disease: Start with 0.5 mg twice daily, and adjust according to clinical response.
• Benign Prostatic Hyperplasia: Start with 0.5 mg twice daily, adjust according to clinical response, up to 2 mg twice daily.

Side Effects:
Common side effects include dizziness, headache, faintness, blurred vision, allergic reactions, nervousness, insomnia, hallucinations, and drowsiness. Rare cases include vertigo, tinnitus, palpitations, and worsening of pre-existing conditions such as narcolepsy.

How to Use:
Take Alphapress XR 5 Tablet with or without food, preferably in the evening with dinner, at least 2-3 hours before bedtime. Dosage should be taken as directed by the physician, and maintenance doses may be taken with or without meals.

Pregnancy & Lactation:
Prazosin is classified as Category C for pregnancy, meaning it should only be used when the benefits outweigh the risks. It is excreted in small amounts in breast milk, so caution is advised when administering to breastfeeding women.

Precautions and warnings:

• Avoid using if allergic to Prazosin or other quinazolines.
• Not suitable for patients with a history of micturition syncope or who are on other alpha-1 agonists.
• Caution is advised for patients with congestive heart failure caused by mechanical obstructions like valve stenosis or pulmonary embolism.
• May cause postural hypotension, especially during the start of therapy.

Safety information:

• Avoid sudden discontinuation to prevent withdrawal symptoms.
• Monitor blood pressure regularly, especially in the early stages of treatment.
• Avoid using alongside other antihypertensive drugs unless advised by a doctor.
• Risk of symptomatic hypotension when used with PDE-5 inhibitors.

Indications:
Alphapress XR 5 is indicated for the treatment of hypertension (primary and secondary), congestive heart failure, Raynaud's phenomenon, and benign prostatic hyperplasia (BPH).

Pharmacology:
Prazosin Hydrochloride works by selectively inhibiting alpha-1 adrenergic receptors, leading to vasodilation and decreased peripheral resistance. It effectively lowers blood pressure without causing reflex tachycardia and improves cardiac output in patients with congestive heart failure. It also alleviates symptoms of BPH by relaxing the smooth muscle in the prostate and bladder neck.

Therapeutic Class:
Alpha-adrenoceptor inhibitors.

Storage Conditions:
Store below 30°C, protected from light and moisture. Keep out of reach of children.

3 FAQ:

1. Can I take Alphapress XR 5 with other blood pressure medications?
   Yes, but consult your doctor for dosage adjustments to avoid a significant drop in blood pressure.
2. Is Alphapress XR 5 safe during pregnancy?
   Prazosin is a Category C drug, so it should only be taken if prescribed by a doctor, considering the potential benefits and risks.
3. What should I do if I miss a dose?
   Take the missed dose as soon as you remember, but skip it if it’s almost time for the next dose. Never double dose.

Disclaimer:
This information is for educational purposes only and should not replace professional medical advice. Always consult your doctor for personalized guidance.

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