Generic
Nabumetone

Description
Alkanon 500 is a non-steroidal anti-inflammatory drug (NSAID) that provides relief from pain and inflammation associated with musculoskeletal and joint disorders, including osteoarthritis and rheumatoid arthritis. It works by inhibiting the synthesis of prostaglandins, which play a key role in inflammation, pain, and fever.

Benefits
Alkanon 500 reduces pain, swelling, and inflammation, making it effective for managing symptoms of osteoarthritis and rheumatoid arthritis. It improves mobility and quality of life by alleviating discomfort and enhancing joint function.

Ingredients
Each tablet contains 500 mg of Nabumetone, a prodrug that is metabolized in the liver to its active form, 6-methoxy-2-naphthylacetic acid (6MNA).

Uses and Doses
Alkanon 500 is indicated for osteoarthritis and rheumatoid arthritis. The recommended starting dose for adults is 1000 mg daily, taken as a single dose with or without food. Dosages can be adjusted to 1500–2000 mg per day based on individual needs but should not exceed 2000 mg daily. In patients with renal insufficiency, doses are adjusted according to renal function. It is not recommended for use in pediatric patients.

Side Effects
Common side effects include gastrointestinal disturbances such as diarrhea, dyspepsia, abdominal pain, nausea, and vomiting. Other potential effects are dizziness, headache, rash, and edema. Rarely, it may cause serious gastrointestinal bleeding, hypertension, or renal impairment.

How to Use
Take Alkanon 500 with food or milk to minimize stomach irritation. Swallow the tablet whole with water. Follow the prescribed dosage and avoid exceeding the recommended daily dose.

Pregnancy & Lactation
Alkanon 500 is classified under Pregnancy Category C. It should only be used during pregnancy if absolutely necessary and avoided during the third trimester due to risks of fetal cardiovascular issues, such as premature closure of the ductus arteriosus. Lactating mothers are advised to avoid the medication due to potential adverse effects on neonates.

Precautions and Warnings
Use with caution in patients with cardiovascular disease, gastrointestinal issues, renal impairment, or liver dysfunction. Elderly patients and those with a history of ulcers or gastrointestinal bleeding should be closely monitored. Avoid use in patients with aspirin allergy or those undergoing coronary artery bypass graft (CABG) surgery.

Safety Information
Do not exceed the prescribed dose. Avoid alcohol as it may increase gastrointestinal side effects. Store the medication out of reach of children.

Indications
Alkanon 500 is used for managing pain and inflammation in osteoarthritis and rheumatoid arthritis.

Pharmacology
Nabumetone, the active ingredient, is a prodrug converted in the liver to 6MNA, an active inhibitor of prostaglandin synthesis. This action helps reduce inflammation, pain, and fever.

Therapeutic Class
Drugs for osteoarthritis and rheumatoid arthritis.

Storage Conditions
Store in a cool, dry place away from light and moisture. Ensure the medicine is kept out of children’s reach.

3 FAQ
What is Alkanon 500 used for?
It is used to relieve pain and inflammation associated with osteoarthritis and rheumatoid arthritis.

Can Alkanon 500 be used during pregnancy?
It is not recommended, especially during the third trimester, due to potential risks to the fetus.

What are the common side effects of Alkanon 500?
Common side effects include gastrointestinal issues such as nausea, diarrhea, and abdominal pain, as well as dizziness and headache.

Disclaimer
This information is provided for educational purposes and should not replace medical advice. Always consult your doctor or pharmacist before using any medication.

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